IL27RA Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms. Belongs to the type I cytokine receptor family. Type 2 subfamily. Highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. Weakly expressed in other tissues examined including heart, brain, fetal and adult lung, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine, kidney and colon. In the lymphoid system, higher level expression in CD4+ T-cell subsets than in CD8+ T-cell subsets. Also weaker expression in CD19+ B-cells and monocytes. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 19p13.12
Cellular Component:  integral component of plasma membrane; plasma membrane
Molecular Function:  transmembrane signaling receptor activity
Biological Process:  cell surface receptor signaling pathway; defense response to Gram-positive bacterium; immune response; interleukin-27-mediated signaling pathway; interleukin-35-mediated signaling pathway; negative regulation of interleukin-17 secretion; negative regulation of interleukin-6 secretion; negative regulation of T cell extravasation; negative regulation of T-helper 17 type immune response; negative regulation of tumor necrosis factor secretion; negative regulation of type 2 immune response; positive regulation of interferon-gamma production; positive regulation of T-helper 1 type immune response; regulation of isotype switching to IgG isotypes
Reference #:  Q6UWB1 (UniProtKB)
Alt. Names/Synonyms: class I cytokine receptor; CRL1; Cytokine receptor WSX-1; Cytokine receptor-like 1; I27RA; IL-27 receptor subunit alpha; IL-27R subunit alpha; IL-27R-alpha; IL-27RA; IL27R; IL27RA; interleukin 27 receptor subunit alpha; interleukin 27 receptor, alpha; Interleukin-27 receptor subunit alpha; T-cell cytokine receptor type 1; TCCR; Type I T-cell cytokine receptor; WSX-1; WSX1; ZcytoR1
Gene Symbols: IL27RA
Molecular weight: 69,474 Da
Basal Isoelectric point: 5.48  Predict pI for various phosphorylation states
CST Pathways:  PI3K/Akt Signaling
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene