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CHST12
Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor. Belongs to the sulfotransferase 2 family. Widely expressed. Expressed a high level in spinal chord, heart, spleen, thyroid, pituitary gland, adrenal gland, peripheral blood leukocytes, thymus, lung, small intestine, fetal kidney, fetal spleen and fetal lung. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.8.2.5; Energy Metabolism - sulfur; Glycan Metabolism - chondroitin sulfate biosynthesis; Membrane protein, integral; Transferase |
| Chromosomal Location of human Ortholog: 7p22.3 |
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Cellular Component:
Golgi membrane
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Molecular Function:
3'-phosphoadenosine 5'-phosphosulfate binding; chondroitin 4-sulfotransferase activity; sulfotransferase activity
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Biological Process:
chondroitin sulfate biosynthetic process; dermatan sulfate biosynthetic process; proteoglycan biosynthetic process
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Reference #:
Q9NRB3
(UniProtKB)
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Alt. Names/Synonyms: C4S-2; C4ST-2; C4ST2; carbohydrate (chondroitin 4) sulfotransferase 12; Carbohydrate sulfotransferase 12; Chondroitin 4-O-sulfotransferase 2; Chondroitin 4-sulfotransferase 2; CHST12; CHSTC; Sulfotransferase Hlo
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Gene Symbols: CHST12
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Molecular weight:
48,414 Da
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Basal Isoelectric point:
9.37
Predict pI for various phosphorylation states
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