Calmodulin Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Mediates calcium-dependent inactivation of CACNA1C. Positively regulates calcium-activated potassium channel activity of KCNN2. Belongs to the calmodulin family. Note: This description may include information from UniProtKB.
Protein type: Calcium-binding; Protein phosphatase, regulatory subunit
Chromosomal Location of mouse Ortholog: 12|12 E
Cellular Component:  calcium channel complex; catalytic complex; centrosome; cytoplasm; cytosol; growth cone; mitochondrial membrane; myelin sheath; nucleoplasm; protein-containing complex; sarcomere; sperm midpiece; spindle microtubule; spindle pole; synaptic vesicle membrane; voltage-gated potassium channel complex
Molecular Function:  adenylate cyclase activator activity; calcium channel inhibitor activity; calcium ion binding; calcium-dependent protein binding; nitric-oxide synthase binding; nitric-oxide synthase regulator activity; phosphatidylinositol 3-kinase binding; protein binding; protein domain specific binding; protein kinase binding; protein phosphatase activator activity; protein serine/threonine kinase activator activity; titin binding; transmembrane transporter binding; type 3 metabotropic glutamate receptor binding
Biological Process:  autophagosome membrane docking; cellular response to interferon-beta; cellular response to type II interferon; detection of calcium ion; G2/M transition of mitotic cell cycle; mitochondrion-endoplasmic reticulum membrane tethering; negative regulation of high voltage-gated calcium channel activity; negative regulation of ryanodine-sensitive calcium-release channel activity; organelle localization by membrane tethering; positive regulation of cyclic-nucleotide phosphodiesterase activity; positive regulation of DNA binding; positive regulation of phosphoprotein phosphatase activity; positive regulation of protein dephosphorylation; positive regulation of receptor signaling pathway via JAK-STAT; positive regulation of ryanodine-sensitive calcium-release channel activity; regulation of cardiac muscle cell action potential; regulation of cardiac muscle contraction; regulation of cytokinesis; regulation of heart rate; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; regulation of ryanodine-sensitive calcium-release channel activity; response to calcium ion
Reference #:  P0DP26 (UniProtKB)
Alt. Names/Synonyms: AI256814; AI327027; AI461935; AL024000; Calm; Calm1; Calm2; Calm3; Calmodulin; calmodulin 1; Calmodulin-1; Calmodulin-2; Calmodulin-3; CaM; Cam1; Cam2; Cam3; Camb; Camc
Gene Symbols: Calm1; Calm2; Calm3
Molecular weight: 16,838 Da
Basal Isoelectric point: 4.09  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein