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Calmodulin
Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Mediates calcium-dependent inactivation of CACNA1C. Positively regulates calcium-activated potassium channel activity of KCNN2. Belongs to the calmodulin family. Note: This description may include information from UniProtKB.
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| Protein type: Calcium-binding; Protein phosphatase, regulatory subunit |
| Chromosomal Location of human Ortholog: 14q32.11 |
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Cellular Component:
calcium channel complex; catalytic complex; centrosome; cytoplasm; cytosol; extracellular region; myelin sheath; nucleoplasm; plasma membrane; protein-containing complex; sarcomere; sperm midpiece; spindle microtubule; spindle pole; voltage-gated potassium channel complex
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Molecular Function:
adenylate cyclase activator activity; calcium channel inhibitor activity; calcium ion binding; calcium-dependent protein binding; protein binding; protein kinase binding; protein phosphatase activator activity; protein serine/threonine kinase activator activity; titin binding; transmembrane transporter binding
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Biological Process:
autophagosome membrane docking; cellular response to interferon-beta; cellular response to type II interferon; detection of calcium ion; G protein-coupled receptor signaling pathway; G2/M transition of mitotic cell cycle; mitochondrion-endoplasmic reticulum membrane tethering; negative regulation of calcium ion export across plasma membrane; negative regulation of high voltage-gated calcium channel activity; negative regulation of peptidyl-threonine phosphorylation; negative regulation of ryanodine-sensitive calcium-release channel activity; organelle localization by membrane tethering; positive regulation of cyclic-nucleotide phosphodiesterase activity; positive regulation of DNA binding; positive regulation of peptidyl-threonine phosphorylation; positive regulation of phosphoprotein phosphatase activity; positive regulation of protein autophosphorylation; positive regulation of protein dephosphorylation; positive regulation of protein serine/threonine kinase activity; positive regulation of receptor signaling pathway via JAK-STAT; positive regulation of ryanodine-sensitive calcium-release channel activity; regulation of calcium-mediated signaling; regulation of cardiac muscle cell action potential; regulation of cardiac muscle contraction; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; regulation of cell communication by electrical coupling involved in cardiac conduction; regulation of cytokinesis; regulation of heart rate; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; regulation of ryanodine-sensitive calcium-release channel activity; response to calcium ion
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Disease: Long Qt Syndrome 14; Ventricular Tachycardia, Catecholaminergic Polymorphic, 4
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Reference #:
P0DP23
(UniProtKB)
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Alt. Names/Synonyms: CALM; CALM1; CALM2; CALM3; CALML2; Calmodulin; calmodulin 1; calmodulin 1 (phosphorylase kinase, delta); calmodulin 2 (phosphorylase kinase, delta); calmodulin 3 (phosphorylase kinase, delta); Calmodulin-1; Calmodulin-2; Calmodulin-3; CAM; CAM1; CAM2; CAM3; CAMB; CAMC; CAMI; CAMIII; CPVT4; DD132; LQT14; PHKD; phosphorylase kinase subunit delta; phosphorylase kinase, delta subunit; prepro-calmodulin 1
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Gene Symbols: CALM1; CALM2; CALM3
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Molecular weight:
16,838 Da
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Basal Isoelectric point:
4.09
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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B Cell Receptor Signaling
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ErbB/HER Signaling
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T Cell Receptor Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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