ALDH3A2
Catalyzes the oxidation of medium and long chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid. Belongs to the aldehyde dehydrogenase family. Detected in liver (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - histidine; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 1.2.1.3; Lipid Metabolism - fatty acid; Lipid Metabolism - glycerolipid; Membrane protein, integral; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation |
Chromosomal Location of human Ortholog: 17p11.2 |
Cellular Component:
cytoplasm; cytosol; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; peroxisomal membrane
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Molecular Function:
3-chloroallyl aldehyde dehydrogenase activity; aldehyde dehydrogenase (NAD+) activity; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity; long-chain-alcohol oxidase activity; long-chain-aldehyde dehydrogenase activity; medium-chain-aldehyde dehydrogenase activity; protein binding; protein homodimerization activity
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Biological Process:
cellular aldehyde metabolic process; central nervous system development; epidermis development; fatty acid metabolic process; hexadecanal metabolic process; peripheral nervous system development; phytol metabolic process
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Disease: Sjogren-larsson Syndrome
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Reference #:
P51648
(UniProtKB)
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Alt. Names/Synonyms: AL3A2; Aldehyde dehydrogenase 10; aldehyde dehydrogenase 3 family member A2; aldehyde dehydrogenase 3 family, member A2; aldehyde dehydrogenase 3A2; Aldehyde dehydrogenase family 3 member A2; ALDH10; ALDH3A2; DKFZp686E23276; FALDH; Fatty aldehyde dehydrogenase; FLJ20851; Microsomal aldehyde dehydrogenase; SLS
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Gene Symbols: ALDH3A2
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Molecular weight:
54,848 Da
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Basal Isoelectric point:
7.98
Predict pI for various phosphorylation states
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