DUSP22 Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK). Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Ubiquitous. Highest expression seen in heart, placenta, lung, liver, kidney and pancreas. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; EC; EC; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity
Chromosomal Location of Human Ortholog: 6p25.3
Cellular Component:  cytoplasm; filamentous actin; leading edge of lamellipodium; nucleus; plasma membrane
Molecular Function:  non-membrane spanning protein tyrosine phosphatase activity; protein tyrosine kinase binding; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity
Biological Process:  cellular response to epidermal growth factor stimulus; negative regulation of cell migration; negative regulation of focal adhesion assembly; negative regulation of non-membrane spanning protein tyrosine kinase activity; negative regulation of T cell activation; negative regulation of T cell mediated immunity; negative regulation of T cell receptor signaling pathway; negative regulation of transcription by RNA polymerase II; peptidyl-tyrosine dephosphorylation
Reference #:  Q9NRW4 (UniProtKB)
Alt. Names/Synonyms: dual specificity phosphatase 22; Dual specificity protein phosphatase 22; DUS22; DUSP22; epididymis secretory sperm binding protein; FLJ35864; homolog of mouse dual specificity phosphatase LMW-DSP2; JKAP; JNK-stimulating phosphatase 1; JNK-stimulatory phosphatase-1; JSP-1; JSP1; LMW-DSP2; LMWDSP2; Low molecular weight dual specificity phosphatase 2; MAP kinase phosphatase x; Mitogen-activated protein kinase phosphatase x; MKP-x; MKPX; VHX
Gene Symbols: DUSP22
Molecular weight: 20,910 Da
Basal Isoelectric point: 8.28  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene