SGK223 Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth. Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism. Acts as a critical coactivator of Notch signaling. Belongs to the protein kinase superfamily. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Motility/polarity/chemotaxis; NKF3 family; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 16q12.2
Cellular Component:  cytoplasm; focal adhesion; nucleus
Molecular Function:  identical protein binding; protein binding; protein kinase activity
Biological Process:  cell migration; negative regulation of neuron projection development; positive regulation of Rho protein signal transduction; protein phosphorylation; regulation of cell motility; regulation of cell shape; regulation of Notch signaling pathway
Reference #:  D3ZMK9 (UniProtKB)
Alt. Names/Synonyms: PEAK1-related kinase-activating pseudokinase 1; pragma of Rnd2; Pragmin; RGD1311793; SGK223; tyrosine-protein kinase SgK223
Gene Symbols: Pragmin
Molecular weight: 147,716 Da
Basal Isoelectric point: 6.97  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein