Smc1 Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint. Belongs to the SMC family. SMC1 subfamily. Note: This description may include information from UniProtKB.
Protein type: DNA replication; RNA splicing
Chromosomal Location of mouse Ortholog: X|X F3
Cellular Component:  chromosome; chromosome, centromeric region; cohesin complex; cytosol; kinetochore; meiotic cohesin complex; mitotic spindle pole; nuclear matrix; nucleoplasm; nucleus
Molecular Function:  ATP binding; chromatin binding; mediator complex binding; nucleotide binding; protein binding; protein heterodimerization activity
Biological Process:  cell cycle; cell division; cellular response to DNA damage stimulus; chromosome organization; DNA repair; meiotic cell cycle; mitotic sister chromatid cohesion; negative regulation of DNA endoreduplication; regulation of mitotic spindle assembly; response to DNA damage checkpoint signaling; sister chromatid cohesion; stem cell population maintenance
Reference #:  Q9CU62 (UniProtKB)
Alt. Names/Synonyms: 5830426I24Rik; Chromosome segregation protein SmcB; KIAA0178; mKIAA0178; OTTMUSP00000021286; SB1.; Sb1.8; segregation of mitotic chromosomes b; SMC (segregation of mitotic chromosomes 1)-like 1; SMC protein 1A; SMC-1-alpha; SMC-1A; Smc1; Smc1a; Smc1alpha; Smc1l1; Smcb; structural maintenance of chromosomes 1A; Structural maintenance of chromosomes protein 1A
Gene Symbols: Smc1a
Molecular weight: 143,235 Da
Basal Isoelectric point: 7.51  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene