Smc1 Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint. Belongs to the SMC family. SMC1 subfamily. Note: This description may include information from UniProtKB.
Protein type: DNA replication; RNA splicing
Chromosomal Location of Human Ortholog: Xp11.22
Cellular Component:  chromosome; chromosome, centromeric region; cohesin complex; condensed chromosome kinetochore; condensed nuclear chromosome; cytosol; kinetochore; meiotic cohesin complex; mitotic spindle pole; nuclear matrix; nucleoplasm; nucleus
Molecular Function:  ATP binding; chromatin binding; mediator complex binding; protein binding; protein heterodimerization activity
Biological Process:  cell division; DNA repair; meiotic cell cycle; mitotic sister chromatid cohesion; mitotic sister chromatid segregation; negative regulation of DNA endoreduplication; regulation of mitotic spindle assembly; response to DNA damage checkpoint signaling; response to radiation; sister chromatid cohesion; stem cell population maintenance
Disease: Cornelia De Lange Syndrome 2; Epileptic Encephalopathy, Early Infantile, 85, With Or Without Midline Brain Defects
Reference #:  Q14683 (UniProtKB)
Alt. Names/Synonyms: CDLS2; DKFZp686L19178; DXS423E; KIAA0178; MGC138332; SB1.8; segregation of mitotic chromosomes 1; SMC protein 1A; SMC-1-alpha; SMC-1A; SMC1; SMC1 (structural maintenance of chromosomes 1, yeast)-like 1; SMC1 structural maintenance of chromosomes 1-like 1; SMC1A; SMC1alpha; SMC1L1; SMCB; structural maintenance of chromosomes 1A; Structural maintenance of chromosomes protein 1A
Gene Symbols: SMC1A
Molecular weight: 143,233 Da
Basal Isoelectric point: 7.51  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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