Smc1 a component of the cohesin multiprotein complex that is required for sister chromatid cohesion. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Thought to be an important part of functional kinetochores. Interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. Note: This description may include information from UniProtKB.
Protein type: DNA replication; RNA splicing
Chromosomal Location of Human Ortholog: Xp11.22
Cellular Component:  chromosome; chromosome, centromeric region; cohesin complex; condensed chromosome kinetochore; condensed nuclear chromosome; cytosol; kinetochore; meiotic cohesin complex; mitotic spindle pole; nuclear matrix; nucleoplasm; nucleus
Molecular Function:  ATP binding; chromatin binding; mediator complex binding; protein binding; protein heterodimerization activity
Biological Process:  cell division; DNA repair; meiotic cell cycle; mitotic sister chromatid cohesion; mitotic sister chromatid segregation; negative regulation of DNA endoreduplication; regulation of mitotic spindle assembly; response to DNA damage checkpoint signaling; response to radiation; sister chromatid cohesion; stem cell population maintenance
Disease: Cornelia De Lange Syndrome 2
Reference #:  Q14683 (UniProtKB)
Alt. Names/Synonyms: CDLS2; DKFZp686L19178; DXS423E; KIAA0178; MGC138332; SB1.8; segregation of mitotic chromosomes 1; SMC protein 1A; SMC-1-alpha; SMC-1A; SMC1; SMC1 (structural maintenance of chromosomes 1, yeast)-like 1; SMC1 structural maintenance of chromosomes 1-like 1; SMC1A; SMC1alpha; SMC1L1; SMCB; structural maintenance of chromosomes 1A; Structural maintenance of chromosomes protein 1A
Gene Symbols: SMC1A
Molecular weight: 143,233 Da
Basal Isoelectric point: 7.51  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Smc1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene