Telethonin Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk. Heart and skeletal muscle. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 17q12
Cellular Component:  cytosol; I band; titin-telethonin complex; Z disc
Molecular Function:  BMP binding; FATZ binding; molecular adaptor activity; protein binding; protein-macromolecule adaptor activity; structural constituent of muscle; titin binding; titin Z domain binding; transmembrane transporter binding
Biological Process:  adult heart development; cardiac muscle cell development; cardiac muscle contraction; cardiac muscle hypertrophy; cardiac muscle hypertrophy in response to stress; cardiac muscle tissue morphogenesis; cardiac myofibril assembly; detection of mechanical stimulus; detection of muscle stretch; otic vesicle formation; protein-containing complex assembly; response to muscle stretch; sarcomere organization; sarcomerogenesis; skeletal muscle contraction; skeletal muscle myosin thick filament assembly; skeletal muscle thin filament assembly; somitogenesis
Disease: Cardiomyopathy, Dilated, 1n; Muscular Dystrophy, Limb-girdle, Type 2g
Reference #:  O15273 (UniProtKB)
Alt. Names/Synonyms: 19 kDa sarcomeric protein; CMD1N; CMH25; LGMD2G; LGMDR7; limb girdle muscular dystrophy 2G (autosomal recessive); T-cap; TCAP; TELE; Telethonin; TELT; teneurin C-terminal associated peptide; Titin cap protein; titin-cap; titin-cap (telethonin)
Gene Symbols: TCAP
Molecular weight: 19,052 Da
Basal Isoelectric point: 5.2  Predict pI for various phosphorylation states
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Telethonin

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene