NOT2 The CCR4-NOT complex functions as general transcription regulation complex. Subunit of the CCR4-NOT core complex that contains CHAF1A, CHAF1B, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6 and CNOT8. Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes. Belongs to the CNOT2/3/5 family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 7q22
Cellular Component:  CCR4-NOT complex; cytoplasm; cytosol; membrane; nucleus; plasma membrane
Molecular Function:  poly(A)-specific ribonuclease activity
Biological Process:  mRNA catabolic process, deadenylation-dependent decay; negative regulation of estrogen receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; negative regulation of translation; regulation of transcription, DNA-templated; trophectodermal cell differentiation
Reference #:  Q5PPJ8 (UniProtKB)
Alt. Names/Synonyms: CCR4-NOT transcription complex, subunit 2; Cnot2
Gene Symbols: Cnot2
Molecular weight: 47,087 Da
Basal Isoelectric point: 8.63  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene