GTF2F2 TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. Belongs to the TFIIF beta subunit family. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.4.12; Helicase; Nuclear receptor co-regulator; Transcription initiation complex
Chromosomal Location of Human Ortholog: 15q11
Cellular Component:  microtubule cytoskeleton; nucleus; transcription factor TFIIF complex; transcription factor TFIIH holo complex; transcriptional preinitiation complex
Molecular Function:  ATP binding; DNA binding; helicase activity
Biological Process:  positive regulation of RNA polymerase II transcriptional preinitiation complex assembly; positive regulation of transcription by RNA polymerase II; positive regulation of transcription elongation from RNA polymerase II promoter; transcription by RNA polymerase II; transcription initiation from RNA polymerase II promoter
Reference #:  Q01750 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent helicase GTF2F2; General transcription factor IIF subunit 2; general transcription factor IIF, polypeptide 2; general transcription factor IIF, polypeptide 2 (30kD subunit); Gtf2f2; Rap30; T2FB; TFIIF-beta; transcription factor gamma; Transcription initiation factor IIF subunit beta; Transcription initiation factor RAP30
Gene Symbols: Gtf2f2
Molecular weight: 28,349 Da
Basal Isoelectric point: 9.23  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
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GTF2F2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA