LIMK2
Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Highest expression in the placenta; moderate level in liver, lung, kidney, and pancreas. LIMK2a is found to be more abundant then LIMK2b in liver, colon, stomach, and spleen, while in brain, kidney, and placenta LIMK2b is the dominant form. In adult lung, both LIMK2a and LIMK2b is nearly equally observed. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: EC 2.7.11.1; Kinase, protein; LIMK subfamily; LISK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group |
Chromosomal Location of mouse Ortholog: 11|11 A1 |
Cellular Component:
centrosome; cis-Golgi network; cytoplasm; cytoskeleton; mitotic spindle; nucleus
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Molecular Function:
ATP binding; kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
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Biological Process:
actin cytoskeleton organization; astral microtubule organization; cornea development in camera-type eye; establishment of vesicle localization; head development; negative regulation of cilium assembly; phosphorylation; positive regulation of protein localization to nucleus; positive regulation of protein phosphorylation; protein phosphorylation; spermatogenesis
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Reference #:
O54785
(UniProtKB)
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Alt. Names/Synonyms: 9430059K01; A930024P04Rik; C85310; Lim; LIM domain kinase 2; LIM kinase 2; LIM motif-containing protein kinase 2; LIM-containing protein kinase 2a; LIM-containing protein kinase 2t; Limk; LIMK-2; Limk2; Limk2a; Limk2b; Limk2t-1 and Limk2t-2; OTTMUSP00000005213; OTTMUSP00000005215; OTTMUSP00000005216; whe
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Gene Symbols: Limk2
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Molecular weight:
72,202 Da
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Basal Isoelectric point:
7.47
Predict pI for various phosphorylation states
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CST Pathways:
TGF-ß Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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