LIMK2 a TKL kinase of the LISK family that regulates actin dynamics. Contains two N-terminal LIM motifs. Phosphorylated and activated by PAK1 and ROCK, downstream effectors of Rho. Phosphorylates cofilin, inhibiting its actin-depolymerizing activity. May contributes to Rho-induced reorganization of the actin cytoskeleton. Two alternative splice variants have been identified. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Kinase, protein; LIMK subfamily; LISK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group
Chromosomal Location of Human Ortholog: 11|11 A1
Cellular Component:  cis-Golgi network; cytoplasm; nucleus
Molecular Function:  ATP binding; kinase activity; metal ion binding; nucleotide binding; protein heterodimerization activity; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  actin cytoskeleton organization; cornea development in camera-type eye; head development; phosphorylation; protein phosphorylation; spermatogenesis
Reference #:  O54785 (UniProtKB)
Alt. Names/Synonyms: 9430059K01; A930024P04Rik; C85310; LIM domain kinase 2; LIM kinase 2; LIM motif-containing protein kinase 2; LIM-containing protein kinase 2a; LIM-containing protein kinase 2t; LIMK-2; Limk2; Limk2a; Limk2b; Limk2t-1 and Limk2t-2; OTTMUSP00000005213; OTTMUSP00000005215; OTTMUSP00000005216
Gene Symbols: Limk2
Molecular weight: 72,202 Da
Basal Isoelectric point: 7.47  Predict pI for various phosphorylation states
CST Pathways:  TGF-ß Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

LIMK2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene