LIMK2 Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Highest expression in the placenta; moderate level in liver, lung, kidney, and pancreas. LIMK2a is found to be more abundant then LIMK2b in liver, colon, stomach, and spleen, while in brain, kidney, and placenta LIMK2b is the dominant form. In adult lung, both LIMK2a and LIMK2b is nearly equally observed. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Kinase, protein; LIMK subfamily; LISK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group
Chromosomal Location of Human Ortholog: 11|11 A1
Cellular Component:  cis-Golgi network; cytoplasm; nucleus
Molecular Function:  ATP binding; kinase activity; metal ion binding; nucleotide binding; protein heterodimerization activity; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  actin cytoskeleton organization; cornea development in camera-type eye; head development; phosphorylation; protein phosphorylation; spermatogenesis
Reference #:  O54785 (UniProtKB)
Alt. Names/Synonyms: 9430059K01; A930024P04Rik; C85310; Lim; LIM domain kinase 2; LIM kinase 2; LIM motif-containing protein kinase 2; LIM-containing protein kinase 2a; LIM-containing protein kinase 2t; Limk; LIMK-2; Limk2; Limk2a; Limk2b; Limk2t-1 and Limk2t-2; OTTMUSP00000005213; OTTMUSP00000005215; OTTMUSP00000005216; whe
Gene Symbols: Limk2
Molecular weight: 72,202 Da
Basal Isoelectric point: 7.47  Predict pI for various phosphorylation states
CST Pathways:  TGF-ß Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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LIMK2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene