DNMT1 Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing. Promotes tumor growth. Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. Ubiquitous; highly expressed in fetal tissues, heart, kidney, placenta, peripheral blood mononuclear cells, and expressed at lower levels in spleen, lung, brain, small intestine, colon, liver, and skeletal muscle. Isoform 2 is less expressed than isoform 1. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC; Methyltransferase; Methyltransferase, DNA; Transcription regulation
Chromosomal Location of Human Ortholog: 8q13
Cellular Component:  cytoplasm; heterochromatin; neuronal cell body; nucleus; pericentric heterochromatin; protein-containing complex; replication fork
Molecular Function:  chromatin binding; DNA (cytosine-5-)-methyltransferase activity; DNA binding; DNA-methyltransferase activity; estrogen receptor binding; histone deacetylase binding; methyl-CpG binding; methyltransferase activity; promoter-specific chromatin binding; protein binding; protein domain specific binding; RNA binding; S-adenosylmethionine-dependent methyltransferase activity; zinc ion binding
Biological Process:  aging; brain development; C-5 methylation of cytosine; cellular response to amino acid stimulus; cellular response to lead ion; cellular response to nerve growth factor stimulus; cellular response to platelet-derived growth factor stimulus; cellular response to transforming growth factor beta stimulus; chromatin organization; DNA hypermethylation; DNA methylation; DNA methylation involved in embryo development; DNA methylation on cytosine; DNA methylation on cytosine within a CG sequence; gene silencing; maintenance of DNA methylation; negative regulation of gene expression; negative regulation of histone H3-K9 methylation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; negative regulation of vascular associated smooth muscle cell apoptotic process; negative regulation of vascular smooth muscle cell differentiation involved in phenotypic switching; neuron differentiation; positive regulation of gene expression; positive regulation of histone H3-K4 methylation; positive regulation of methylation-dependent chromatin silencing; positive regulation of vascular smooth muscle cell proliferation; Ras protein signal transduction; regulation of cell proliferation; regulation of gene expression; response to activity; response to caffeine; response to drug; response to estradiol; response to ethanol; response to heat; response to ionizing radiation; response to lead ion; response to lipopolysaccharide; response to nutrient levels; response to organic substance; response to testosterone; response to toxic substance; response to vitamin A; S-adenosylmethionine metabolic process
Reference #:  Q9Z330 (UniProtKB)
Alt. Names/Synonyms: DNA (cytosine-5)-methyltransferase 1; DNA (cytosine-5-)-methyltransferase 1; DNA methyltransferase (cytosine-5) 1; DNA methyltransferase I; DNA MTase RnoIP; Dnmt1; M.RnoIP; MCMT
Gene Symbols: Dnmt1
Molecular weight: 182,774 Da
Basal Isoelectric point: 8.46  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene