DAB1
Adapter molecule functioning in neural development. May regulate SIAH1 activity. Mainly expressed in brain. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Adaptor/scaffold |
Chromosomal Location of rat Ortholog: 5q33-q34 |
Cellular Component:
apical part of cell; brush border; cytoplasm; intracellular membrane-bounded organelle; neuronal cell body; perinuclear region of cytoplasm
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Molecular Function:
phosphatidylinositol 3-kinase binding
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Biological Process:
adult walking behavior; astrocyte differentiation; axonogenesis; cell adhesion; cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration; cerebellum structural organization; cerebral cortex cell migration; cerebral cortex development; cerebral cortex radially oriented cell migration; dendrite development; Golgi localization; hippocampus development; lateral motor column neuron migration; midgut development; motor neuron migration; negative regulation of astrocyte differentiation; negative regulation of axonogenesis; negative regulation of cell adhesion; negative regulation of receptor signaling pathway via JAK-STAT; neuron differentiation; neuron migration; positive regulation of neuron differentiation; positive regulation of protein kinase activity; radial glia guided migration of Purkinje cell; radial glia-guided pyramidal neuron migration; receptor signaling pathway via JAK-STAT; response to xenobiotic stimulus; small GTPase mediated signal transduction; ventral spinal cord development
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Reference #:
Q8CJH2
(UniProtKB)
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Alt. Names/Synonyms: Dab1; Disabled homolog 1; disabled homolog 1 (Drosophila)
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Gene Symbols: Dab1
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Molecular weight:
59,900 Da
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Basal Isoelectric point:
4.98
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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