Rhodopsin Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of the chromophore 11-cis-retinal to all-trans-retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling. Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. Rod shaped photoreceptor cells which mediate vision in dim light. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 3q22.1
Cellular Component:  cell-cell junction; ciliary membrane; Golgi apparatus; Golgi membrane; Golgi-associated vesicle membrane; integral component of membrane; photoreceptor disc membrane; photoreceptor inner segment; photoreceptor inner segment membrane; photoreceptor outer segment; photoreceptor outer segment membrane; plasma membrane
Molecular Function:  11-cis retinal binding; G protein-coupled photoreceptor activity; G protein-coupled receptor activity; metal ion binding; protein binding
Biological Process:  absorption of visible light; G protein-coupled receptor signaling pathway; photoreceptor cell maintenance; phototransduction, visible light; protein phosphorylation; protein-chromophore linkage; regulation of rhodopsin mediated signaling pathway; retina development in camera-type eye; retinoid metabolic process; rhodopsin mediated signaling pathway; visual perception
Disease: Fundus Albipunctatus; Night Blindness, Congenital Stationary, Autosomal Dominant 1; Retinitis Pigmentosa 4
Reference #:  P08100 (UniProtKB)
Alt. Names/Synonyms: CSNBAD1; MGC138309; MGC138311; OPN2; OPSD; opsin 2, rod pigment; Opsin-2; retinitis pigmentosa 4, autosomal dominant; RHO; Rhodopsin; rhodopsin (opsin 2, rod pigment) (retinitis pigmentosa 4, autosomal dominant); RP4
Gene Symbols: RHO
Molecular weight: 38,893 Da
Basal Isoelectric point: 6.21  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene