EEF1A1 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. Brain, placenta, lung, liver, kidney, pancreas but barely detectable in heart and skeletal muscle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; Translation; Translation elongation
Chromosomal Location of Human Ortholog: 8q31
Cellular Component:  cortical actin cytoskeleton; cytoplasm; cytosol; nucleolus; nucleus; plasma membrane; ruffle membrane
Molecular Function:  calmodulin binding; drug binding; GTP binding; GTPase activity; mRNA binding; protein kinase binding; translation elongation factor activity; tRNA binding
Biological Process:  aging; cellular response to drug; cellular response to epidermal growth factor stimulus; cellular response to nerve growth factor stimulus; negative regulation of reactive oxygen species biosynthetic process; positive regulation of cell death; positive regulation of neuron projection development; protein homooligomerization; regulation of D-erythro-sphingosine kinase activity; translation; translational elongation
Reference #:  P62630 (UniProtKB)
Alt. Names/Synonyms: EEF-1; Eef1a; eEF1A-1; Eef1a1; Eef1a2; Eef1a2l1; EF-1 alpha2; EF-1-alpha-1; EF-Tu; EF1A; EF1A1; elongation factor 1 A-1; Elongation factor 1-alpha 1; Elongation factor Tu; Eukaryotic elongation factor 1 A-1; eukaryotic translation elongation factor 1 alpha 1; eukaryotic translation elongation factor 1 alpha 2 like 1; MGC125172; SI
Gene Symbols: Eef1a1
Molecular weight: 50,114 Da
Basal Isoelectric point: 9.1  Predict pI for various phosphorylation states
CST Pathways:  Translational Control
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene