Rhodopsin Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of the chromophore 11-cis-retinal to all-trans-retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling. Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. Rod shaped photoreceptor cells which mediate vision in dim light. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 6 E3|6 53.72 cM
Cellular Component:  cell projection; cell-cell junction; Golgi apparatus; integral component of membrane; integral component of plasma membrane; membrane; photoreceptor disc membrane; photoreceptor inner segment; photoreceptor inner segment membrane; photoreceptor outer segment; photoreceptor outer segment membrane; plasma membrane; rough endoplasmic reticulum membrane
Molecular Function:  G protein-coupled photoreceptor activity; G protein-coupled receptor activity; metal ion binding; photoreceptor activity; protein binding; retinal binding; spectrin binding
Biological Process:  cellular response to light stimulus; detection of light stimulus; G protein-coupled receptor signaling pathway; photoreceptor cell maintenance; phototransduction; protein phosphorylation; protein-chromophore linkage; red, far-red light phototransduction; response to light stimulus; response to stimulus; retina development in camera-type eye; rhodopsin mediated signaling pathway; sensory perception of light stimulus; signal transduction; visual perception
Reference #:  P15409 (UniProtKB)
Alt. Names/Synonyms: L opsin; Long Wavelength Sensitive opsin; LWS opsin; MGC21585; MGC25387; Noe; Noerg1; Opn2; Ops; OPSD; opsin 2; Red Opsin; Rho; Rhodopsin; Rod Opsin; RP4
Gene Symbols: Rho
Molecular weight: 39,070 Da
Basal Isoelectric point: 6.21  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene