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Rhodopsin
Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of the chromophore 11-cis-retinal to all-trans-retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling. Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. Rod shaped photoreceptor cells which mediate vision in dim light. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Chromosomal Location of Human Ortholog: 6 E3|6 53.72 cM |
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Cellular Component:
cell projection; cell-cell junction; Golgi apparatus; integral component of membrane; integral component of plasma membrane; membrane; photoreceptor disc membrane; photoreceptor inner segment; photoreceptor inner segment membrane; photoreceptor outer segment; photoreceptor outer segment membrane; plasma membrane; rough endoplasmic reticulum membrane
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Molecular Function:
G protein-coupled photoreceptor activity; G protein-coupled receptor activity; metal ion binding; photoreceptor activity; protein binding; retinal binding; spectrin binding
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Biological Process:
cellular response to light stimulus; detection of light stimulus; G protein-coupled receptor signaling pathway; photoreceptor cell maintenance; phototransduction; protein phosphorylation; protein-chromophore linkage; red, far-red light phototransduction; response to light stimulus; response to stimulus; retina development in camera-type eye; rhodopsin mediated signaling pathway; sensory perception of light stimulus; signal transduction; visual perception
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Reference #:
P15409
(UniProtKB)
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Alt. Names/Synonyms: L opsin; Long Wavelength Sensitive opsin; LWS opsin; MGC21585; MGC25387; Noerg1; Opn2; Ops; OPSD; opsin 2; Red Opsin; Rho; Rhodopsin; Rod Opsin; RP4
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Gene Symbols: Rho
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Molecular weight:
39,070 Da
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Basal Isoelectric point:
6.21
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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