hnRNP A1
Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May bind to specific miRNA hairpins. (Microbial infection) May play a role in HCV RNA replication. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Nuclear export; RNA splicing; RNA-binding; Spliceosome |
Chromosomal Location of rat Ortholog: 7q36 |
Cellular Component:
catalytic step 2 spliceosome; cytoplasm; intracellular non-membrane-bounded organelle; nucleoplasm; nucleoplasmic periphery of the nuclear pore complex; nucleus; ribonucleoprotein complex; spliceosomal complex; synapse
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Molecular Function:
DNA binding; DNA/DNA annealing activity; G-rich strand telomeric DNA binding; identical protein binding; miRNA binding; molecular condensate scaffold activity; mRNA 3'-UTR binding; mRNA binding; pre-mRNA binding; protein binding; protein domain specific binding; RNA binding; RNA strand annealing activity; sequence-specific mRNA binding; single-stranded DNA binding; single-stranded RNA binding; telomeric repeat-containing RNA binding
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Biological Process:
alternative mRNA splicing, via spliceosome; amyloid fibril formation; cellular response to epidermal growth factor stimulus; cellular response to glucose starvation; cellular response to organic substance; cellular response to potassium ion; cellular response to sodium arsenite; import into nucleus; localization; lung development; male gonad development; mRNA processing; mRNA splicing, via spliceosome; mRNA transport; negative regulation of telomere maintenance via telomerase; nuclear export; positive regulation of action potential; positive regulation of gene expression; positive regulation of telomere maintenance via telomerase; regulation of alternative mRNA splicing, via spliceosome; regulation of RNA splicing; response to endoplasmic reticulum stress; RNA metabolic process; RNA splicing
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Reference #:
P04256
(UniProtKB)
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Alt. Names/Synonyms: HDP; Helix-destabilizing protein; Heterogeneous nuclear ribonucleoprotein A1; hnRNP A1; hnRNP core protein A1; Hnrnpa1; Hnrpa1; ROA1; Single-strand RNA-binding protein
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Gene Symbols: Hnrnpa1
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Molecular weight:
34,212 Da
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Basal Isoelectric point:
9.2
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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