CAMK1A an ubiquitous protein kinase of the CAMK1 family. Activated by Ca(2+)/calmodulin. Must be phosphorylated to be maximally active. Substrates include synapsin I. Note: This description may include information from UniProtKB.
Protein type: CAMK group; CAMK1 family; EC; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 6 E3|6 52.75 cM
Cellular Component:  cytoplasm; glutamatergic synapse; nucleus; postsynaptic density
Molecular Function:  ATP binding; calmodulin binding; calmodulin-dependent protein kinase activity; catalytic activity; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  cell cycle; cell differentiation; metabolic process; multicellular organism development; negative regulation of protein binding; nervous system development; nucleocytoplasmic transport; phosphorylation; positive regulation of dendritic spine development; positive regulation of muscle cell differentiation; positive regulation of neuron projection development; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein acetylation; positive regulation of protein export from nucleus; positive regulation of protein serine/threonine kinase activity; positive regulation of synapse structural plasticity; positive regulation of syncytium formation by plasma membrane fusion; positive regulation of transcription by RNA polymerase II; protein phosphorylation; regulation of muscle cell differentiation; regulation of protein binding; regulation of protein localization; regulation of synapse organization; signal transduction
Reference #:  Q91YS8 (UniProtKB)
Alt. Names/Synonyms: AI505105; calcium/calmodulin-dependent protein kinase I; Calcium/calmodulin-dependent protein kinase type 1; CaM kinase I; CaM kinase I alpha; CaM-KI; Camk1; CaMKI-alpha; CaMKIalpha; D6Ertd263e; KCC1A; OTTMUSP00000025539
Gene Symbols: Camk1
Molecular weight: 41,624 Da
Basal Isoelectric point: 5.19  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Microtubule Dynamics
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Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene