CAMK1A Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-276' and 'Ser-295'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation. Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. Widely expressed. Expressed in cells of the zona glomerulosa of the adrenal cortex. Note: This description may include information from UniProtKB.
Protein type: CAMK group; CAMK1 family; EC 2.7.11.17; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 6 E3|6 52.75 cM
Cellular Component:  cytoplasm; glutamatergic synapse; nucleus; postsynaptic density
Molecular Function:  ATP binding; calmodulin binding; calmodulin-dependent protein kinase activity; catalytic activity; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  cell cycle; cell differentiation; metabolic process; multicellular organism development; negative regulation of protein binding; nervous system development; nucleocytoplasmic transport; phosphorylation; positive regulation of dendritic spine development; positive regulation of muscle cell differentiation; positive regulation of neuron projection development; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein acetylation; positive regulation of protein export from nucleus; positive regulation of protein serine/threonine kinase activity; positive regulation of synapse structural plasticity; positive regulation of syncytium formation by plasma membrane fusion; positive regulation of transcription by RNA polymerase II; protein phosphorylation; regulation of muscle cell differentiation; regulation of protein binding; regulation of protein localization; regulation of synapse organization; signal transduction
Reference #:  Q91YS8 (UniProtKB)
Alt. Names/Synonyms: AI505105; calcium/calmodulin-dependent protein kinase I; Calcium/calmodulin-dependent protein kinase type 1; Cam; CaM kinase I; CaM kinase I alpha; CaM-KI; Camk; Camk1; CAMK1A; CaMKI-alpha; CaMKIalpha; D6Ertd263; D6Ertd263e; KCC1A; OTTMUSP00000025539
Gene Symbols: Camk1
Molecular weight: 41,624 Da
Basal Isoelectric point: 5.19  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Microtubule Dynamics
Select Structure to View Below

CAMK1A

Protein Structure Not Found.


Substrate Sequence Logo
Open Substrate Page

Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene