PKCB Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1. Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: AGC group; Alpha subfamily; EC 2.7.11.13; Kinase, protein; Motility/polarity/chemotaxis; PKC family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 7 F2|7 65.75 cM
Cellular Component:  brush border membrane; calyx of Held; centrosome; cytoplasm; cytosol; membrane; nucleoplasm; nucleus; plasma membrane; presynaptic cytosol
Molecular Function:  androgen receptor binding; ATP binding; calcium channel regulator activity; chromatin binding; histone binding; histone kinase activity (H3-T6 specific); kinase activity; metal ion binding; nuclear receptor transcription coactivator activity; nucleotide binding; protein binding; protein kinase activity; protein kinase C activity; protein kinase C binding; protein serine/threonine kinase activity; transferase activity; zinc ion binding
Biological Process:  adaptive immune response; apoptotic process; B cell activation; B cell receptor signaling pathway; calcium ion transport; cellular calcium ion homeostasis; cellular response to carbohydrate stimulus; chromatin organization; histone H3-T6 phosphorylation; immune system process; intracellular signal transduction; negative regulation of glucose transmembrane transport; negative regulation of insulin receptor signaling pathway; peptidyl-serine phosphorylation; phosphorylation; positive regulation of angiogenesis; positive regulation of B cell receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of NF-kappaB transcription factor activity; positive regulation of vascular endothelial growth factor receptor signaling pathway; presynaptic modulation of chemical synaptic transmission; protein phosphorylation; regulation of dopamine secretion; regulation of growth; regulation of synaptic vesicle exocytosis; regulation of transcription by RNA polymerase II; response to drug; response to hypoxia
Reference #:  P68404 (UniProtKB)
Alt. Names/Synonyms: A130082F03Rik; KPCB; OTTMUSP00000017803; Pkc; PKC-B; PKC-Be; PKC-Beta; Pkcb; Prkc; Prkcb; Prkcb protein; Prkcb1; Prkcb2; Protein kinase C beta type; protein kinase C beta-II; protein kinase C, beta; protein kinase C, beta 1
Gene Symbols: Prkcb
Molecular weight: 76,751 Da
Basal Isoelectric point: 6.57  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis  |  Phospholipase Signaling  |  Protein Kinase C Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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PKCB

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Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein