CDK5R1 p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution. Belongs to the cyclin-dependent kinase 5 activator family. Brain and neuron specific. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 11 B5|11 47.94 cM
Cellular Component:  axon; contractile fiber; cytoplasm; dendrite; dendritic spine; growth cone; intracellular membrane-bounded organelle; membrane; neuromuscular junction; neuronal cell body; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; presynapse; protein kinase 5 complex
Molecular Function:  actin binding; actin filament binding; cadherin binding; calcium ion binding; cyclin-dependent protein serine/threonine kinase activator activity; cytoskeletal protein binding; ephrin receptor binding; ionotropic glutamate receptor binding; kinase activity; protease binding; protein binding; protein kinase binding; protein serine/threonine kinase activator activity
Biological Process:  axon guidance; axonal fasciculation; brain development; cerebellum development; cerebral cortex radially oriented cell migration; embryo development ending in birth or egg hatching; ephrin receptor signaling pathway; G protein-coupled acetylcholine receptor signaling pathway; hippocampus development; ionotropic glutamate receptor signaling pathway; layer formation in cerebral cortex; negative regulation of axon extension; negative regulation of transcription, DNA-templated; neuron cell-cell adhesion; neuron differentiation; neuron migration; neuron projection development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of cell cycle arrest; positive regulation of neuron apoptotic process; positive regulation of protein kinase activity; positive regulation of protein targeting to membrane; regulation of actin cytoskeleton organization; regulation of dendritic spine morphogenesis; regulation of microtubule cytoskeleton organization; regulation of synaptic vesicle cycle; rhythmic process; serine phosphorylation of STAT protein; superior olivary nucleus maturation
Reference #:  P61809 (UniProtKB)
Alt. Names/Synonyms: CD5R1; CDK5 activator 1; Cdk5r; Cdk5r1; Cyclin-dependent kinase 5 activator 1; Cyclin-dependent kinase 5 activator 1, p25; Cyclin-dependent kinase 5 activator 1, p35; Cyclin-dependent kinase 5 regulatory subunit 1; cyclin-dependent kinase 5, regulatory subunit (p35) 1; cyclin-dependent kinase 5, regulatory subunit 1 (p35); D11Bwg0379e; Nck5a; OTTMUSP00000000280; p23; p25; p35; Tau protein kinase II 23 kDa subunit; TPKII regulatory subunit
Gene Symbols: Cdk5r1
Molecular weight: 34,031 Da
Basal Isoelectric point: 9.44  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene