PLXNA3 Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Belongs to the plexin family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of human Ortholog: Xq28
Cellular Component:  cell junction; intracellular membrane-bounded organelle; membrane; nucleus; plasma membrane; semaphorin receptor complex
Molecular Function:  protein binding; transmembrane signaling receptor activity
Biological Process:  branchiomotor neuron axon guidance; facial nerve structural organization; hippocampus development; multicellular organism development; negative chemotaxis; negative regulation of axon extension involved in axon guidance; neuron projection extension; positive regulation of cytoskeleton organization; pyramidal neuron development; semaphorin-plexin signaling pathway; trigeminal nerve structural organization
Reference #:  P51805 (UniProtKB)
Alt. Names/Synonyms: 6.3; HSSEXGENE; plexin 4; plexin A3; Plexin-4; Plexin-A3; PLXA3; PLXN3; PLXN4; PLXNA3; Semaphorin receptor SEX; SEX; Sex chromosome X transmembrane protein of HGF receptor family 3; XAP-6
Gene Symbols: PLXNA3
Molecular weight: 207,717 Da
Basal Isoelectric point: 7.06  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene