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JIP3
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration. Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development. Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation. Belongs to the JIP scaffold family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 16p13.3 |
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Cellular Component:
axon; axon cytoplasm; cell body; cytoplasm; cytoplasmic vesicle; dendrite; Golgi membrane; growth cone; perinuclear region of cytoplasm
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Molecular Function:
JUN kinase binding; kinesin binding; MAP-kinase scaffold activity; protein binding; signaling receptor complex adaptor activity
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Biological Process:
anterograde axonal protein transport; axon development; axon regeneration; negative regulation of apoptotic process; positive regulation of JNK cascade; protein stabilization; regulation of JNK cascade; vesicle-mediated transport
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Disease: Neurodevelopmental Disorder With Or Without Variable Brain Abnormalities
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Reference #:
Q9UPT6
(UniProtKB)
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Alt. Names/Synonyms: C-jun-amino-terminal kinase interacting protein 3; C-Jun-amino-terminal kinase-interacting protein 3; DKFZp762N1113; FLJ00027; homolog of Drosophila Sunday driver 2; JIP-3; JIP3; JNK MAP kinase scaffold protein 3; JNK-interacting protein 3; JNK/SAPK-associated protein-1; JNK/stress-activated protein kinase-associated protein 1; JSAP1; KIAA1066; MAPK8IP3; mitogen-activated protein kinase 8 interacting protein 3; Mitogen-activated protein kinase 8-interacting protein 3; NEDBA; syd; SYD2
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Gene Symbols: MAPK8IP3
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Molecular weight:
147,457 Da
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Basal Isoelectric point:
5.26
Predict pI for various phosphorylation states
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CST Pathways:
SAPK/JNK Signaling Cascades
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