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GJA1
Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles. Belongs to the connexin family. Alpha-type (group II) subfamily. Expressed in the heart and fetal cochlea. Note: This description may include information from UniProtKB.
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| Protein type: Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis |
| Chromosomal Location of rat Ortholog: 20q11 |
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Cellular Component:
apical plasma membrane; cell junction; cell-cell contact zone; cell-cell junction; connexin complex; contractile fiber; cytoplasm; cytosol; early endosome; endoplasmic reticulum; endoplasmic reticulum membrane; endosome; fascia adherens; gap junction; Golgi apparatus; Golgi membrane; Golgi-associated vesicle membrane; intercalated disc; intermediate filament; intracellular membrane-bounded organelle; late endosome; lateral plasma membrane; lysosome; membrane; membrane raft; mitochondrial outer membrane; mitochondrion; multivesicular body; nucleoplasm; nucleus; plasma membrane; protein-containing complex; tight junction
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Molecular Function:
alpha-tubulin binding; beta-catenin binding; beta-tubulin binding; connexin binding; disordered domain specific binding; efflux transmembrane transporter activity; gap junction channel activity; gap junction channel activity involved in cell communication by electrical coupling; gap junction hemi-channel activity; glutathione transmembrane transporter activity; molecular adaptor activity; monoatomic ion transmembrane transporter activity; PDZ domain binding; protein binding; protein domain specific binding; protein tyrosine kinase binding; scaffold protein binding; SH3 domain binding; signaling receptor binding; transmembrane transporter activity; tubulin binding
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Biological Process:
adult heart development; ATP transport; atrial ventricular junction remodeling; blood vessel morphogenesis; bone development; bone remodeling; cardiac conduction; cell communication by chemical coupling; cell communication by electrical coupling; cell-cell junction organization; cell-cell signaling; cellular response to amyloid-beta; cellular response to mechanical stimulus; cellular response to parathyroid hormone stimulus; cellular response to pH; cellular response to platelet-derived growth factor stimulus; chronic inflammatory response; columnar/cuboidal epithelial cell maturation; decidualization; embryonic digit morphogenesis; embryonic heart tube development; endothelium development; epididymis development; establishment of mitotic spindle orientation; export across plasma membrane; gap junction assembly; glutamate secretion; glutathione transmembrane transport; heart development; heart looping; in utero embryonic development; lens development in camera-type eye; maintenance of protein localization in endoplasmic reticulum; male gonad development; microtubule-based transport; milk ejection reflex; monoatomic ion transmembrane transport; negative regulation of cardiac muscle cell proliferation; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of DNA biosynthetic process; negative regulation of endothelial cell proliferation; negative regulation of gene expression; negative regulation of gonadotropin secretion; negative regulation of trophoblast cell migration; neuroblast migration; neuron migration; neuron projection morphogenesis; osteoblast differentiation; positive regulation of behavioral fear response; positive regulation of cell communication by chemical coupling; positive regulation of cold-induced thermogenesis; positive regulation of cytosolic calcium ion concentration; positive regulation of establishment of Sertoli cell barrier; positive regulation of gene expression; positive regulation of glomerular filtration; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of insulin secretion; positive regulation of meiotic nuclear division; positive regulation of mesodermal cell differentiation; positive regulation of morphogenesis of an epithelium; positive regulation of protein catabolic process; positive regulation of smooth muscle cell chemotaxis; positive regulation of stem cell proliferation; positive regulation of striated muscle tissue development; positive regulation of vascular associated smooth muscle cell proliferation; positive regulation of vasoconstriction; protein localization; regulation of actin filament organization; regulation of apoptotic process; regulation of atrial cardiac muscle cell membrane depolarization; regulation of bicellular tight junction assembly; regulation of bone mineralization; regulation of bone remodeling; regulation of calcium ion transport; regulation of cell communication by electrical coupling; regulation of heart contraction; regulation of transmembrane transporter activity; regulation of ventricular cardiac muscle cell membrane depolarization; regulation of ventricular cardiac muscle cell membrane repolarization; response to estradiol; response to fluid shear stress; response to glucose; response to ischemia; response to lipopolysaccharide; response to peptide hormone; response to pH; response to retinoic acid; response to wounding; signal transduction; skeletal muscle tissue regeneration; spermatogenesis; T cell activation; T cell proliferation; transmembrane transport; vascular transport; vasodilation; xenobiotic transport
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Reference #:
P08050
(UniProtKB)
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Alt. Names/Synonyms: connexin 43; Connexin-43; Cx43; Cxn-43; Gap junction 43 kDa heart protein; Gap junction alpha-1 protein; gap junction membrane channel protein alpha 1; gap junction protein, alpha 1; Gja1; MGC93610
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Gene Symbols: Gja1
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Molecular weight:
43,031 Da
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Basal Isoelectric point:
8.97
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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