SESN3 a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Chromosomal Location of Human Ortholog: 11q21
Cellular Component:  cytoplasm; nucleus
Molecular Function:  protein binding
Biological Process:  cellular response to amino acid starvation; cellular response to glucose starvation; glucose homeostasis; negative regulation of TORC1 signaling; oxidation-reduction process; regulation of insulin receptor signaling pathway; regulation of protein kinase B signaling; regulation of response to reactive oxygen species; response to insulin; TORC2 signaling
Reference #:  P58005 (UniProtKB)
Alt. Names/Synonyms: MGC29667; SESN3; SEST3; sestrin 3; Sestrin-3
Gene Symbols: SESN3
Molecular weight: 57,291 Da
Basal Isoelectric point: 5.84  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene