SESN3
May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway. May also regulate the insulin-receptor signaling pathway through activation of TORC2. This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses. Belongs to the sestrin family. Widely expressed. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Chromosomal Location of human Ortholog: 11q21 |
Cellular Component:
cytoplasm; nucleus; TORC2 complex
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Molecular Function:
leucine binding; oxidoreductase activity, acting on peroxide as acceptor; protein binding
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Biological Process:
cellular response to amino acid starvation; cellular response to glucose starvation; cellular response to leucine; cellular response to leucine starvation; glucose homeostasis; negative regulation of TORC1 signaling; positive regulation of macroautophagy; regulation of insulin receptor signaling pathway; regulation of protein kinase B signaling; regulation of response to reactive oxygen species; response to insulin; TORC2 signaling
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Reference #:
P58005
(UniProtKB)
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Alt. Names/Synonyms: MGC29667; SESN3; SEST3; sestrin 3; Sestrin-3
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Gene Symbols: SESN3
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Molecular weight:
57,291 Da
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Basal Isoelectric point:
5.84
Predict pI for various phosphorylation states
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CST Pathways:
AMPK Signaling
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