SESN3 May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway. May also regulate the insulin-receptor signaling pathway through activation of TORC2. This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses. Belongs to the sestrin family. Widely expressed. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 11q21
Cellular Component:  cytoplasm; nucleus
Molecular Function:  protein binding
Biological Process:  cellular response to amino acid starvation; cellular response to glucose starvation; glucose homeostasis; negative regulation of TORC1 signaling; oxidation-reduction process; regulation of insulin receptor signaling pathway; regulation of protein kinase B signaling; regulation of response to reactive oxygen species; response to insulin; TORC2 signaling
Reference #:  P58005 (UniProtKB)
Alt. Names/Synonyms: MGC29667; SESN3; SEST3; sestrin 3; Sestrin-3
Gene Symbols: SESN3
Molecular weight: 57,291 Da
Basal Isoelectric point: 5.84  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene