CCNA2 Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. Belongs to the cyclin family. Cyclin AB subfamily. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Nuclear receptor co-regulator
Chromosomal Location of human Ortholog: 4q27
Cellular Component:  cyclin A2-CDK2 complex; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytosol; female pronucleus; male pronucleus; nucleoplasm; nucleus
Molecular Function:  cyclin-dependent protein serine/threonine kinase regulator activity; protein binding; protein domain specific binding; protein kinase binding
Biological Process:  animal organ regeneration; cell cycle G1/S phase transition; cell division; cellular response to cocaine; cellular response to estradiol stimulus; cellular response to hypoxia; cellular response to insulin-like growth factor stimulus; cellular response to leptin stimulus; cellular response to luteinizing hormone stimulus; cellular response to nitric oxide; cellular response to platelet-derived growth factor stimulus; cochlea development; DNA-templated transcription; G2/M transition of mitotic cell cycle; mitotic cell cycle phase transition; positive regulation of DNA-templated transcription; positive regulation of fibroblast proliferation; post-translational protein modification; Ras protein signal transduction; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of DNA replication; response to glucagon
Reference #:  P20248 (UniProtKB)
Alt. Names/Synonyms: CCN1; CCNA; CCNA2; Cyclin A; cyclin A2; Cyclin-A; Cyclin-A2
Gene Symbols: CCNA2
Molecular weight: 48,551 Da
Basal Isoelectric point: 6.1  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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CCNA2
Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA