|
IPO11
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of UBE2E3, and of RPL12. Belongs to the importin beta family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Karyopherin; Nuclear import |
| Chromosomal Location of human Ortholog: 5q12.1 |
|
Cellular Component:
cytosol; nuclear envelope; nucleoplasm
|
|
Molecular Function:
nuclear import signal receptor activity; protein binding; small GTPase binding
|
|
Biological Process:
protein import into nucleus; ribosomal protein import into nucleus
|
|
Reference #:
Q9UI26
(UniProtKB)
|
|
Alt. Names/Synonyms: Imp11; importin 11; Importin-11; IPO11; Ran binding protein 11; Ran-binding protein 11; RANBP11
|
|
Gene Symbols: IPO11
|
|
Molecular weight:
112,535 Da
|
|
Basal Isoelectric point:
5.14
Predict pI for various phosphorylation states
|
