TRIO Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases. Involved in coordinating actin remodeling, which is necessary for cell migration and growth. In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses. May act as a regulator of adipogenesis. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Widely expressed, with highest levels in heart, skeletal muscle, and brain. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; CAMK group; EC; GEF; GEF, misc.; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Trio family
Chromosomal Location of human Ortholog: 5p15.2
Cellular Component:  cell projection; cytoplasm; cytosol; extrinsic component of membrane; glutamatergic synapse; postsynapse; presynaptic active zone
Molecular Function:  ATP binding; guanyl-nucleotide exchange factor activity; protein binding; protein serine kinase activity; protein serine/threonine kinase activity
Biological Process:  axon guidance; negative regulation of fat cell differentiation; neuron projection morphogenesis; postsynaptic modulation of chemical synaptic transmission; protein phosphorylation; regulation of small GTPase mediated signal transduction; transmembrane receptor protein tyrosine phosphatase signaling pathway
Disease: Intellectual Developmental Disorder, Autosomal Dominant 63, With Macrocephaly; Mental Retardation, Autosomal Dominant 44
Reference #:  O75962 (UniProtKB)
Alt. Names/Synonyms: ARHGEF23; FLJ42780; MEBAS; MRD44; MRD63; PTPRF-interacting protein; tgat; TRIO; trio Rho guanine nucleotide exchange factor; triple functional domain (PTPRF interacting); Triple functional domain protein
Gene Symbols: TRIO
Molecular weight: 346,900 Da
Basal Isoelectric point: 5.94  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein