POLR2C DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft. Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex
Chromosomal Location of human Ortholog: 16q21
Cellular Component:  cytosol; nucleoplasm; nucleus; RNA polymerase II, core complex
Molecular Function:  DNA binding; DNA-directed 5'-3' RNA polymerase activity; protein binding; protein dimerization activity
Biological Process:  transcription by RNA polymerase II
Reference #:  P19387 (UniProtKB)
Alt. Names/Synonyms: DNA-directed RNA polymerase II 33 kDa polypeptide; DNA-directed RNA polymerase II subunit C; DNA-directed RNA polymerase II subunit RPB3; hRPB33; hsRPB3; POLR2C; polymerase (RNA) II (DNA directed) polypeptide C, 33kDa; polymerase (RNA) II subunit C; RNA polymerase II subunit 3; RNA polymerase II subunit B3; RNA polymerase II subunit C; RPB3; RPB31; RPB33
Gene Symbols: POLR2C
Molecular weight: 31,441 Da
Basal Isoelectric point: 4.79  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene