TRIP10
Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling. Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL. Belongs to the FNBP1 family. Expressed in brain, colon, heart, kidney, liver, lung, megakaryocyte, ovary, pancreas, peripheral blood lymphocytes, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus and trachea. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator |
Chromosomal Location of mouse Ortholog: 17|17 D |
Cellular Component:
cell projection; cytoplasm; cytoskeleton; Golgi apparatus; intracellular membrane-bounded organelle; lysosome; membrane; microtubule; nucleoplasm; plasma membrane
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Molecular Function:
identical protein binding; lipid binding; protein binding
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Biological Process:
endocytosis; epithelial to mesenchymal transition; negative regulation of cardiac muscle cell apoptotic process; positive regulation of cell growth involved in cardiac muscle cell development; signal transduction
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Reference #:
Q8CJ53
(UniProtKB)
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Alt. Names/Synonyms: AI646975; Cdc42 interacting protein-4; Cdc42-interacting protein 4; Cip4; thyroid hormone receptor interactor 10; Thyroid receptor-interacting protein 10; TR-interacting protein 10; TRIP-10; Trip10
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Gene Symbols: Trip10
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Molecular weight:
68,489 Da
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Basal Isoelectric point:
5.66
Predict pI for various phosphorylation states
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CST Pathways:
Adherens Junction Dynamics
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Insulin Receptor Signaling
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