ITGAL
Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R. Integin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages. Belongs to the integrin alpha chain family. Leukocytes. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis |
Chromosomal Location of human Ortholog: 16p11.2 |
Cellular Component:
cell surface; external side of plasma membrane; integrin alphaL-beta2 complex; integrin complex; plasma membrane; specific granule membrane
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Molecular Function:
cell adhesion molecule binding; ICAM-3 receptor activity; integrin binding; metal ion binding; protein binding
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Biological Process:
cell adhesion; cell adhesion mediated by integrin; cell-cell adhesion; cell-matrix adhesion; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; inflammatory response; integrin-mediated signaling pathway; leukocyte cell-cell adhesion; memory T cell extravasation; phagocytosis; receptor clustering; signal transduction; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
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Reference #:
P20701
(UniProtKB)
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Alt. Names/Synonyms: alpha polypeptide); antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide; CD11 antigen-like family member A; CD11A; Integrin alpha-L; integrin gene promoter; integrin subunit alpha L; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; ITAL; ITGAL; Leukocyte adhesion glycoprotein LFA-1 alpha chain; Leukocyte function-associated molecule 1 alpha chain; LFA-1; LFA-1 alpha; LFA-1A; LFA1A; lymphocyte function-associated antigen 1; lymphocyte function-associated antigen 1, alpha polypeptide
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Gene Symbols: ITGAL
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Molecular weight:
128,770 Da
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Basal Isoelectric point:
5.4
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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GPCR Signaling to MAPKs
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Growth And Differentiation Control by MAPKs
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PI3K/Akt Signaling
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T Cell Receptor Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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