BOK Isoform 1: Apoptosis regulator that functions through different apoptotic signaling pathways. Plays a roles as pro-apoptotic protein that positively regulates intrinsic apoptotic process in a BAX- and BAK1-dependent manner or in a BAX- and BAK1-independent manner. In response to endoplasmic reticulum stress promotes mitochondrial apoptosis through downstream BAX/BAK1 activation and positive regulation of PERK-mediated unfolded protein response. Activates apoptosis independently of heterodimerization with survival-promoting BCL2 and BCL2L1 through induction of mitochondrial outer membrane permeabilization, in a BAX- and BAK1-independent manner, in response to inhibition of ERAD-proteasome degradation system, resulting in cytochrome c release. In response to DNA damage, mediates intrinsic apoptotic process in a TP53-dependent manner. Plays a role in granulosa cell apoptosis by CASP3 activation. Plays a roles as anti-apoptotic protein during neuronal apoptotic process, by negatively regulating poly ADP-ribose polymerase-dependent cell death through regulation of neuronal calcium homeostasis and mitochondrial bioenergetics in response to NMDA excitation. In addition to its role in apoptosis, may regulate trophoblast cell proliferation during the early stages of placental development, by acting on G1/S transition through regulation of CCNE1 expression. May also play a role as an inducer of autophagy by disrupting interaction between MCL1 and BECN1. Isoform 2: Pro-apoptotic molecule exerting its function through the mitochondrial pathway. Belongs to the Bcl-2 family. Expressed mainly in oocytes; weak expression in granulosa cells of the developing follicles. In adult human ovaries, expressed in granulosa cells at all follicular stages, but expression in primordial/primary follicles granulosa cell is stronger than in secondary and antral follicles. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Chromosomal Location of human Ortholog: 2q37.3
Cellular Component:  cis-Golgi network membrane; cytoplasm; early endosome membrane; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; integral component of membrane; mitochondrial inner membrane; mitochondrial membrane; mitochondrion; nuclear outer membrane; nucleus; recycling endosome membrane; trans-Golgi network membrane
Molecular Function:  BH domain binding; protein binding; protein heterodimerization activity; protein homodimerization activity; signaling receptor binding; ubiquitin protein ligase binding
Biological Process:  activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; apoptotic process; brain development; cell proliferation; cellular component disassembly involved in execution phase of apoptosis; intrinsic apoptotic signaling pathway by p53 class mediator; male gonad development; negative regulation of mitochondrial depolarization; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; negative regulation of necroptotic process; negative regulation of neuron apoptotic process; neuron apoptotic process; oligodendrocyte differentiation; positive regulation of apoptotic process; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; positive regulation of execution phase of apoptosis; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; positive regulation of PERK-mediated unfolded protein response; protein complex oligomerization; regulation of autophagy; regulation of chorionic trophoblast cell proliferation; regulation of cytosolic calcium ion concentration; regulation of granulosa cell apoptotic process; release of cytochrome c from mitochondria
Reference #:  Q9UMX3 (UniProtKB)
Alt. Names/Synonyms: Bcl-2-like protein 9; Bcl-2-related ovarian killer protein; BCL2 family apoptosis regulator BOK; BCL2 related ovarian killer; Bcl2-L-9; BCL2-related ovarian killer; BCL2L9; BOK; BOK, BCL2 family apoptosis regulator; BOKL; hBOK; MGC4631
Gene Symbols: BOK
Molecular weight: 23,280 Da
Basal Isoelectric point: 9.33  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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BOK

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene