TFCP2 Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1. Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter. Belongs to the grh/CP2 family. CP2 subfamily. Ubiquitous. Expressed in brain, ovary, kidney, thymus, spleen, liver, adrenal, heart and lung (at protein level). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 12q13.12-q13.13
Cellular Component:  cytosol; nucleoplasm; nucleus; protein-containing complex
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; proximal promoter sequence-specific DNA binding; RNA polymerase II proximal promoter sequence-specific DNA binding; transcription factor binding
Biological Process:  mRNA transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II
Reference #:  Q12800 (UniProtKB)
Alt. Names/Synonyms: Alpha-globin transcription factor CP2; LBP1C; LSF; LSF1D; SAA3 enhancer factor; SEF; TFCP2; TFCP2C; transcription factor CP2; Transcription factor LSF
Gene Symbols: TFCP2
Molecular weight: 57,256 Da
Basal Isoelectric point: 5.53  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein