MLKL Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity. Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function. Belongs to the protein kinase superfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group; TKL-Unique family
Chromosomal Location of Human Ortholog: 16q23.1
Cellular Component:  cytoplasm; cytosol; plasma membrane
Molecular Function:  ATP binding; protein binding; protein kinase binding; protein-containing complex binding
Biological Process:  activation of JNKK activity; cell surface receptor signaling pathway; necroptotic process; protein homotrimerization
Reference #:  Q8NB16 (UniProtKB)
Alt. Names/Synonyms: FLJ34389; mixed lineage kinase domain-like; Mixed lineage kinase domain-like protein; MLKL
Gene Symbols: MLKL
Molecular weight: 54,479 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MLKL

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein