MLKL Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity. Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function. Belongs to the protein kinase superfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group; TKL-Unique family

Chromosomal Location of human Ortholog: 16q23.1

Cellular Component: cell junction; cytoplasm; cytosol; nucleus; plasma membrane

Molecular Function: ATP binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; protein-containing complex binding

Biological Process: cell surface receptor signaling pathway; defense response to virus; execution phase of necroptosis; necroptotic process; necroptotic signaling pathway; protein homotrimerization; protein phosphorylation

Reference #: Q8NB16 (UniProtKB)

Alt. Names/Synonyms: FLJ34389; hMLKL; mixed lineage kinase domain like pseudokinase; mixed lineage kinase domain-like; Mixed lineage kinase domain-like protein; MLKL

Gene Symbols: MLKL

Molecular weight: 54,479 Da

Basal Isoelectric point: 9 Predict pI for various phosphorylation states

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

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MLKL

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