MISR2 On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.30; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; STKR family; TKL group; Type2 subfamily
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component:  plasma membrane
Molecular Function:  anti-Mullerian hormone receptor activity; ATP binding; hormone binding; metal ion binding; protein binding
Biological Process:  anti-Mullerian hormone signaling pathway; BMP signaling pathway; female gonad development; male gonad development; Mullerian duct regression; protein phosphorylation; sex differentiation
Disease: Persistent Mullerian Duct Syndrome, Types I And Ii
Reference #:  Q16671 (UniProtKB)
Alt. Names/Synonyms: AMH type II receptor; AMHR; AMHR2; Anti-Muellerian hormone type II receptor; Anti-Muellerian hormone type-2 receptor; anti-Mullerian hormone receptor type 2; anti-Mullerian hormone receptor, type II; MIS type II receptor; MISR2; MISRII; MRII; Muellerian inhibiting substance type II receptor; Mullerian inhibiting substance type II receptor
Gene Symbols: AMHR2
Molecular weight: 62,750 Da
Basal Isoelectric point: 5.53  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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MISR2

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein