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ALK7
Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Present in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.30; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; STKR family; TKL group; Type1 subfamily |
| Chromosomal Location of human Ortholog: 2q24.1 |
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Cellular Component:
activin receptor complex; plasma membrane; receptor complex
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Molecular Function:
activin receptor activity, type I; ATP binding; growth factor binding; metal ion binding; nodal binding; protein serine/threonine kinase activity
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Biological Process:
activin receptor signaling pathway; apoptotic nuclear changes; cell differentiation; cellular response to growth factor stimulus; insulin secretion; lipid storage; negative regulation of chorionic trophoblast cell proliferation; negative regulation of insulin secretion; negative regulation of trophoblast cell migration; nervous system development; nodal signaling pathway; positive regulation of apoptotic process; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; protein phosphorylation; response to dietary excess; response to glucose; response to insulin; trophectodermal cell proliferation
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Reference #:
Q8NER5
(UniProtKB)
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Alt. Names/Synonyms: activin A receptor type 1C; activin A receptor, type IC; Activin receptor type IC; Activin receptor type-1C; Activin receptor-like kinase 7; ACTR-IC; ACV1C; ACVR1C; ACVRLK7; ALK-7; ALK7
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Gene Symbols: ACVR1C
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Molecular weight:
54,871 Da
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Basal Isoelectric point:
8.22
Predict pI for various phosphorylation states
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