ALK7 Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Present in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; STKR family; STKR1 subfamily; TKL group
Chromosomal Location of human Ortholog: 2q24.1
Cellular Component:  activin receptor complex; plasma membrane
Molecular Function:  activin receptor activity, type I; ATP binding; growth factor binding; metal ion binding; nodal binding; protein serine/threonine kinase activity
Biological Process:  activin receptor signaling pathway; apoptotic nuclear changes; cell differentiation; cellular response to growth factor stimulus; insulin secretion; lipid storage; negative regulation of chorionic trophoblast cell proliferation; negative regulation of insulin secretion; negative regulation of trophoblast cell migration; nervous system development; nodal signaling pathway; positive regulation of apoptotic process; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; protein phosphorylation; response to dietary excess; response to glucose; response to insulin; trophectodermal cell proliferation
Reference #:  Q8NER5 (UniProtKB)
Alt. Names/Synonyms: activin A receptor type 1C; activin A receptor, type IC; Activin receptor type IC; Activin receptor type-1C; Activin receptor-like kinase 7; ACTR-IC; ACV1C; ACVR1C; ACVRLK7; ALK-7; ALK7
Gene Symbols: ACVR1C
Molecular weight: 54,871 Da
Basal Isoelectric point: 8.22  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein