BMPR1A a serine/threonine-protein kinase receptor for Bone morphogenetic protein-2 and -4 (BMP-2 and BMP-4). Defects in BMPR1A are a cause of juvenile polyposis syndrome (JPS) and Cowden disease (CD), a cancer syndrome characterized by multiple hamartomas and by a high risk for breast, thyroid and endometriel cancers. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.30; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; STKR family; TKL group; Type1 subfamily
Chromosomal Location of Human Ortholog: 16p15
Cellular Component:  caveola; cell surface; dendrite; external side of plasma membrane; integral component of plasma membrane; neuronal cell body; plasma membrane; receptor complex
Molecular Function:  ATP binding; BMP receptor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; growth factor binding; metal ion binding; protein homodimerization activity; protein serine/threonine kinase activity; SMAD binding; transforming growth factor beta receptor activity, type I; transforming growth factor beta-activated receptor activity
Biological Process:  anterior/posterior pattern specification; BMP signaling pathway; cardiac conduction system development; cardiac right ventricle morphogenesis; cartilage development; cell differentiation; cellular response to BMP stimulus; chondrocyte differentiation; developmental growth; dorsal aorta morphogenesis; dorsal/ventral axis specification; dorsal/ventral pattern formation; ectoderm development; embryonic digit morphogenesis; embryonic morphogenesis; embryonic organ development; endocardial cushion formation; endocardial cushion morphogenesis; endoderm development; fibrous ring of heart morphogenesis; heart development; heart formation; heart morphogenesis; hindlimb morphogenesis; immune response; in utero embryonic development; lateral mesoderm development; lung development; mesendoderm development; mesoderm formation; mitral valve morphogenesis; Mullerian duct regression; negative regulation of neurogenesis; negative regulation of smooth muscle cell migration; nervous system development; neural crest cell development; neural plate mediolateral regionalization; neural plate pattern specification; odontogenesis of dentin-containing tooth; outflow tract morphogenesis; outflow tract septum morphogenesis; paraxial mesoderm development; paraxial mesoderm structural organization; pattern specification process; pharyngeal arch artery morphogenesis; pituitary gland development; positive regulation of bone mineralization; positive regulation of cardiac muscle cell proliferation; positive regulation of cardiac ventricle development; positive regulation of epithelial cell proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of osteoblast differentiation; positive regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of pri-miRNA transcription by RNA polymerase II; positive regulation of SMAD protein signal transduction; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; positive regulation of vascular smooth muscle cell proliferation; protein phosphorylation; regulation of cardiac muscle cell proliferation; regulation of cellular senescence; regulation of lateral mesodermal cell fate specification; roof of mouth development; somitogenesis; stem cell population maintenance; transforming growth factor beta receptor signaling pathway; tricuspid valve morphogenesis; ventricular compact myocardium morphogenesis; ventricular trabecula myocardium morphogenesis
Reference #:  Q78EA7 (UniProtKB)
Alt. Names/Synonyms: Activin receptor-like kinase 3; ALK-3; BMP type-1A receptor; BMPR-1A; Bmpr1a; BMR1A; Bone morphogenetic protein 4 receptor; Bone morphogenetic protein receptor type-1A; bone morphogenetic protein receptor, type 1A; bone morphogenetic protein receptor, type IA
Gene Symbols: Bmpr1a
Molecular weight: 59,994 Da
Basal Isoelectric point: 7.1  Predict pI for various phosphorylation states
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BMPR1A

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene