BMPR1A On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Highly expressed in skeletal muscle. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.30; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; STKR family; TKL group; Type1 subfamily
Chromosomal Location of mouse Ortholog: 14 B|14 20.81 cM
Cellular Component:  cell surface; dendrite; external side of plasma membrane; integral component of membrane; integral component of plasma membrane; membrane; neuronal cell body; plasma membrane; receptor complex
Molecular Function:  ATP binding; BMP receptor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; growth factor binding; kinase activity; metal ion binding; nucleotide binding; protein binding; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activity; SMAD binding; transferase activity; transforming growth factor beta receptor activity, type I; transforming growth factor beta-activated receptor activity; transmembrane receptor protein serine/threonine kinase activity
Biological Process:  anterior/posterior pattern specification; BMP signaling pathway; BMP signaling pathway involved in heart development; cardiac conduction system development; cardiac right ventricle morphogenesis; cartilage development; cell differentiation; cellular response to BMP stimulus; chondrocyte differentiation; developmental growth; dorsal aorta morphogenesis; dorsal/ventral axis specification; dorsal/ventral pattern formation; ectoderm development; embryonic digit morphogenesis; embryonic morphogenesis; embryonic organ development; endocardial cushion formation; endocardial cushion morphogenesis; endoderm development; fibrous ring of heart morphogenesis; heart development; heart formation; heart morphogenesis; hindlimb morphogenesis; immune response; in utero embryonic development; lateral mesoderm development; lung development; mesendoderm development; mesoderm formation; mitral valve morphogenesis; Mullerian duct regression; negative regulation of neurogenesis; negative regulation of smooth muscle cell migration; nervous system development; neural crest cell development; neural plate mediolateral regionalization; neural plate pattern specification; odontogenesis of dentin-containing tooth; outflow tract morphogenesis; outflow tract septum morphogenesis; paraxial mesoderm development; paraxial mesoderm structural organization; pattern specification process; pharyngeal arch artery morphogenesis; phosphorylation; pituitary gland development; positive regulation of bone mineralization; positive regulation of cardiac muscle cell proliferation; positive regulation of cardiac ventricle development; positive regulation of epithelial cell proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of osteoblast differentiation; positive regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of pri-miRNA transcription by RNA polymerase II; positive regulation of SMAD protein signal transduction; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; positive regulation of vascular smooth muscle cell proliferation; protein phosphorylation; regulation of cardiac muscle cell proliferation; regulation of cellular senescence; regulation of lateral mesodermal cell fate specification; roof of mouth development; somitogenesis; stem cell population maintenance; transforming growth factor beta receptor signaling pathway; tricuspid valve morphogenesis; ventricular compact myocardium morphogenesis; ventricular trabecula myocardium morphogenesis
Reference #:  P36895 (UniProtKB)
Alt. Names/Synonyms: 1110037I22Rik; Activin receptor-like kinase 3; Acvrlk3; ALK-3; ALK3; AU045487; BMP; BMP type-1A receptor; BMP-2/BMP-4 receptor; Bmpr; BMPR-1A; BMPR-IA; Bmpr1a; BMR1A; Bone morphogenetic protein receptor type-1A; bone morphogenetic protein receptor, type 1A; CD292; Serine/threonine-protein kinase receptor R5; SKR5
Gene Symbols: Bmpr1a
Molecular weight: 60,063 Da
Basal Isoelectric point: 7.1  Predict pI for various phosphorylation states
Select Structure to View Below

BMPR1A

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene