BMPR1A On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Highly expressed in skeletal muscle. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; STKR family; TKL group; Type1 subfamily
Chromosomal Location of human Ortholog: 10q23.2
Cellular Component:  caveola; dendrite; external side of plasma membrane; HFE-transferrin receptor complex; membrane; neuronal cell body; plasma membrane; receptor complex
Molecular Function:  ATP binding; BMP binding; BMP receptor activity; metal ion binding; phosphatase activator activity; protein binding; protein homodimerization activity; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; SMAD binding; transforming growth factor beta receptor activity, type I; transmembrane receptor protein serine/threonine kinase activity
Biological Process:  angiogenesis; atrioventricular node cell development; atrioventricular valve development; BMP signaling pathway; BMP signaling pathway involved in heart development; cardiac conduction system development; cardiac right ventricle morphogenesis; cellular response to BMP stimulus; cellular response to growth factor stimulus; central nervous system neuron differentiation; chondrocyte differentiation; developmental growth; dorsal aorta morphogenesis; dorsal/ventral axis specification; dorsal/ventral pattern formation; ectoderm development; embryonic digit morphogenesis; embryonic organ development; endocardial cushion formation; endocardial cushion morphogenesis; epithelial cell proliferation; fibrous ring of heart morphogenesis; heart formation; hindlimb morphogenesis; immune response; in utero embryonic development; lateral mesoderm development; lung development; mesendoderm development; mesoderm formation; mitral valve morphogenesis; Mullerian duct regression; negative regulation of gene expression; negative regulation of muscle cell differentiation; negative regulation of neurogenesis; negative regulation of smooth muscle cell migration; neural crest cell development; neural plate mediolateral regionalization; odontogenesis of dentin-containing tooth; osteoblast differentiation; outflow tract morphogenesis; outflow tract septum morphogenesis; paraxial mesoderm structural organization; pharyngeal arch artery morphogenesis; pituitary gland development; positive regulation of bone mineralization; positive regulation of cardiac muscle cell proliferation; positive regulation of cardiac ventricle development; positive regulation of epithelial cell proliferation; positive regulation of gene expression; positive regulation of mesenchymal cell proliferation; positive regulation of miRNA transcription; positive regulation of osteoblast differentiation; positive regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of protein serine/threonine kinase activity; positive regulation of SMAD protein signal transduction; positive regulation of transcription by RNA polymerase II; positive regulation of transforming growth factor beta2 production; positive regulation of vascular associated smooth muscle cell proliferation; protein phosphorylation; regulation of cardiac muscle cell apoptotic process; regulation of cardiac muscle cell proliferation; regulation of cellular senescence; regulation of lateral mesodermal cell fate specification; regulation of neural crest cell differentiation; roof of mouth development; somatic stem cell population maintenance; somitogenesis; transforming growth factor beta receptor signaling pathway; tricuspid valve morphogenesis; ventricular compact myocardium morphogenesis; ventricular septum morphogenesis; ventricular trabecula myocardium morphogenesis
Disease: Juvenile Polyposis Syndrome; Polyposis Syndrome, Hereditary Mixed, 2
Reference #:  P36894 (UniProtKB)
Alt. Names/Synonyms: 10q23del; activin A receptor, type II-like kinase 3; Activin receptor-like kinase 3; ACVRLK3; ALK-3; ALK3; BMP type-1A receptor; BMPR-1A; BMPR1A; BMPRIA; BMR1A; bone morphogenetic protein receptor type 1A; Bone morphogenetic protein receptor type-1A; bone morphogenetic protein receptor, type IA; CD292; Serine/threonine-protein kinase receptor R5; SKR5
Gene Symbols: BMPR1A
Molecular weight: 60,198 Da
Basal Isoelectric point: 7.71  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene