BMPR1A On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Highly expressed in skeletal muscle. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.30; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; STKR family; TKL group; Type1 subfamily
Chromosomal Location of human Ortholog: 10q23.2
Cellular Component:  dendrite; external side of plasma membrane; HFE-transferrin receptor complex; integral component of membrane; neuronal cell body; plasma membrane
Molecular Function:  ATP binding; BMP receptor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding; protein binding; protein homodimerization activity; protein serine/threonine kinase activity; SMAD binding; transmembrane receptor protein serine/threonine kinase activity
Biological Process:  BMP signaling pathway; BMP signaling pathway involved in heart development; cardiac conduction system development; cardiac right ventricle morphogenesis; cellular response to BMP stimulus; chondrocyte differentiation; developmental growth; dorsal aorta morphogenesis; dorsal/ventral axis specification; ectoderm development; embryonic digit morphogenesis; embryonic organ development; endocardial cushion formation; endocardial cushion morphogenesis; fibrous ring of heart morphogenesis; heart formation; hindlimb morphogenesis; immune response; in utero embryonic development; lateral mesoderm development; lung development; mesendoderm development; mesoderm formation; mitral valve morphogenesis; Mullerian duct regression; negative regulation of neurogenesis; negative regulation of smooth muscle cell migration; neural crest cell development; neural plate mediolateral regionalization; odontogenesis of dentin-containing tooth; outflow tract morphogenesis; outflow tract septum morphogenesis; paraxial mesoderm structural organization; pharyngeal arch artery morphogenesis; pituitary gland development; positive regulation of bone mineralization; positive regulation of cardiac muscle cell proliferation; positive regulation of cardiac ventricle development; positive regulation of epithelial cell proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of osteoblast differentiation; positive regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of pri-miRNA transcription by RNA polymerase II; positive regulation of SMAD protein signal transduction; positive regulation of transcription by RNA polymerase II; positive regulation of vascular smooth muscle cell proliferation; protein phosphorylation; regulation of cardiac muscle cell proliferation; regulation of cellular senescence; regulation of lateral mesodermal cell fate specification; roof of mouth development; somitogenesis; stem cell population maintenance; tricuspid valve morphogenesis; ventricular compact myocardium morphogenesis; ventricular trabecula myocardium morphogenesis
Disease: Juvenile Polyposis Syndrome; Polyposis Syndrome, Hereditary Mixed, 2
Reference #:  P36894 (UniProtKB)
Alt. Names/Synonyms: 10q23del; activin A receptor, type II-like kinase 3; Activin receptor-like kinase 3; ACVRLK3; ALK-3; ALK3; BMP type-1A receptor; BMPR-1A; BMPR1A; BMPRIA; BMR1A; bone morphogenetic protein receptor type 1A; Bone morphogenetic protein receptor type-1A; bone morphogenetic protein receptor, type IA; CD292; Serine/threonine-protein kinase receptor R5; SKR5
Gene Symbols: BMPR1A
Molecular weight: 60,198 Da
Basal Isoelectric point: 7.71  Predict pI for various phosphorylation states
Select Structure to View Below

BMPR1A

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene