RASGRP4 Functions as a cation- and diacylglycerol (DAG)- regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast cells differentiation. Belongs to the RASGRP family. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Ras
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component:  cytosol; membrane; plasma membrane
Molecular Function:  calcium ion binding; diacylglycerol binding; GTP-dependent protein binding; Ras guanyl-nucleotide exchange factor activity
Biological Process:  activation of phospholipase C activity; cell proliferation; MAPK cascade; myeloid cell differentiation; positive regulation of Ras protein signal transduction; regulation of G protein-coupled receptor signaling pathway; response to extracellular stimulus; small GTPase mediated signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  Q8TDF6 (UniProtKB)
Alt. Names/Synonyms: GRP4; guanyl nucleotide releasing protein 4; RAS guanyl releasing protein 4; RAS guanyl-releasing protein 4; RASGRP4
Gene Symbols: RASGRP4
Molecular weight: 74,882 Da
Basal Isoelectric point: 8.34  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  GPCR Signaling to MAPKs
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RASGRP4

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein