KSR a serine/threonine kinase of the Raf family with no demonstrated kinase activity. A location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. Interacts with RAF and MAPK/ERK, in a Ras-dependent manner. The binding of 14-3-3 proteins to phosphorylated KSR prevents the membrane localization. In unstimulated cells, the phosphorylated form is bound to a 14-3-3 protein and sequestered in the cytoplasm. Translocates from the cytoplasm to the cell periphery following TNF treatment. When Bad is available, ceramide signaling through the Ras/Raf cascade can lead to apoptosis. Three alternatively-spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; RAF family; TKL group
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component:  cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; membrane; protein-containing complex; ruffle membrane
Molecular Function:  14-3-3 protein binding; ATP binding; chaperone binding; Hsp90 protein binding; MAP-kinase scaffold activity; metal ion binding; mitogen-activated protein kinase kinase binding; protein binding; protein C-terminus binding; protein kinase activity
Biological Process:  cAMP-mediated signaling; MAPK cascade; positive regulation of MAPK cascade; Ras protein signal transduction; regulation of cell proliferation; regulation of MAP kinase activity
Reference #:  Q8IVT5 (UniProtKB)
Alt. Names/Synonyms: kinase suppressor of ras; Kinase suppressor of Ras 1; KSR; KSR1; RSU2
Gene Symbols: KSR1
Molecular weight: 102,160 Da
Basal Isoelectric point: 8.94  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene