MLK4 Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; MLK family; MLK subfamily; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group
Chromosomal Location of human Ortholog: 1q42.2
Cellular Component:  cytoplasm
Molecular Function:  ATP binding; JUN kinase kinase kinase activity; protein binding; protein homodimerization activity; protein kinase activity; protein serine kinase activity
Biological Process:  MAPK cascade; protein autophosphorylation; protein phosphorylation; signal transduction
Reference #:  Q5TCX8 (UniProtKB)
Alt. Names/Synonyms: dJ862P8.3; KIAA1804; M3K21; M3KL4; MAP3K21; Mitogen-activated protein kinase kinase kinase; Mitogen-activated protein kinase kinase kinase 21; Mitogen-activated protein kinase kinase kinase MLK4; Mixed lineage kinase 4; MLK4; RP5-862P8.2
Gene Symbols: MAP3K21
Molecular weight: 113,957 Da
Basal Isoelectric point: 8.97  Predict pI for various phosphorylation states
CST Pathways:  SAPK/JNK Signaling Cascades
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein