IRAK3 Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. Expressed predominantly in peripheral blood lymphocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; IRAK family; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group
Chromosomal Location of Human Ortholog: 10|10 D2
Cellular Component:  cytoplasm; nucleus; plasma membrane
Molecular Function:  ATP binding; kinase activity; magnesium ion binding; nucleotide binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  apoptotic process; cytokine-mediated signaling pathway; interleukin-1-mediated signaling pathway; intracellular signal transduction; MyD88-dependent toll-like receptor signaling pathway; negative regulation of cytokine-mediated signaling pathway; negative regulation of innate immune response; negative regulation of interleukin-12 production; negative regulation of interleukin-6 production; negative regulation of macrophage cytokine production; negative regulation of MAP kinase activity; negative regulation of NF-kappaB transcription factor activity; negative regulation of protein catabolic process; negative regulation of protein complex disassembly; negative regulation of toll-like receptor signaling pathway; negative regulation of tumor necrosis factor production; phosphorylation; positive regulation of macrophage tolerance induction; positive regulation of NF-kappaB transcription factor activity; protein autophosphorylation; protein phosphorylation; regulation of apoptotic process; regulation of protein complex disassembly; response to exogenous dsRNA; response to interleukin-1; response to lipopolysaccharide; response to peptidoglycan; response to virus; signal transduction
Reference #:  Q8K4B2 (UniProtKB)
Alt. Names/Synonyms: 4833428C18Rik; AI563835; IL-1 receptor-associated kinase M; Interleukin-1 receptor-associated kinase 3; IRA; IRAK-3; IRAK-M; Irak3
Gene Symbols: Irak3
Molecular weight: 68,455 Da
Basal Isoelectric point: 6.33  Predict pI for various phosphorylation states
CST Pathways:  Toll-Like Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene