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IRAK3
Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. Expressed predominantly in peripheral blood lymphocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.1; IRAK family; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group |
| Chromosomal Location of human Ortholog: 12q14.3 |
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Cellular Component:
cytoplasm; nucleus; plasma membrane
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Molecular Function:
ATP binding; magnesium ion binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase binding; protein serine/threonine kinase activity
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Biological Process:
cellular response to lipopolysaccharide; cytokine-mediated signaling pathway; interleukin-1-mediated signaling pathway; intracellular signal transduction; MyD88-dependent toll-like receptor signaling pathway; negative regulation of cytokine-mediated signaling pathway; negative regulation of innate immune response; negative regulation of interleukin-12 production; negative regulation of interleukin-6 production; negative regulation of macrophage cytokine production; negative regulation of MAP kinase activity; negative regulation of NF-kappaB transcription factor activity; negative regulation of protein catabolic process; negative regulation of protein-containing complex disassembly; negative regulation of toll-like receptor signaling pathway; negative regulation of tumor necrosis factor production; positive regulation of cytokine production; positive regulation of macrophage tolerance induction; positive regulation of NF-kappaB transcription factor activity; protein autophosphorylation; protein phosphorylation; regulation of protein-containing complex disassembly; response to exogenous dsRNA; response to interleukin-1; response to lipopolysaccharide; response to peptidoglycan; response to virus; Toll signaling pathway
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Disease: Asthma-related Traits, Susceptibility To, 5
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Reference #:
Q9Y616
(UniProtKB)
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Alt. Names/Synonyms: ASRT5; FLJ13601; IL-1 receptor-associated kinase M; interleukin 1 receptor associated kinase 3; Interleukin-1 receptor-associated kinase 3; interleukin-1 receptor-associated kinase M; IRAK-3; IRAK-M; IRAK3; IRAKM
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Gene Symbols: IRAK3
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Molecular weight:
67,767 Da
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Basal Isoelectric point:
6.25
Predict pI for various phosphorylation states
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CST Pathways:
Toll-Like Receptor Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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