BMPR2
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Highly expressed in heart and liver. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Cell cycle regulation; EC 2.7.11.30; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; STKR family; STKR2 subfamily; TKL group |
Chromosomal Location of mouse Ortholog: 1|1 C2 |
Cellular Component:
adherens junction; apical plasma membrane; axon; basal plasma membrane; caveola; cell body; cell surface; clathrin-coated pit; dendrite; membrane; neuronal cell body; nucleoplasm; plasma membrane; postsynaptic density; receptor complex
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Molecular Function:
ATP binding; BMP binding; BMP receptor activity; cadherin binding; growth factor binding; kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase binding; transferase activity; transforming growth factor beta receptor activity; transmembrane receptor protein serine/threonine kinase activity
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Biological Process:
anterior/posterior pattern specification; aortic valve development; artery development; atrial septum morphogenesis; atrioventricular valve morphogenesis; blood vessel development; blood vessel remodeling; BMP signaling pathway; cardiac muscle tissue development; cellular response to BMP stimulus; cellular response to growth factor stimulus; chondrocyte development; endocardial cushion development; endothelial cell apoptotic process; endothelial cell proliferation; limb development; lung alveolus development; lymphangiogenesis; lymphatic endothelial cell differentiation; maternal placenta development; mesoderm formation; mitral valve morphogenesis; negative regulation of cell growth; negative regulation of cell proliferation involved in heart valve morphogenesis; negative regulation of chondrocyte proliferation; negative regulation of DNA biosynthetic process; negative regulation of muscle cell differentiation; negative regulation of smooth muscle cell proliferation; negative regulation of systemic arterial blood pressure; negative regulation of vasoconstriction; osteoblast differentiation; outflow tract morphogenesis; outflow tract septum morphogenesis; pharyngeal arch artery morphogenesis; phosphorylation; positive regulation of axon extension involved in axon guidance; positive regulation of BMP signaling pathway; positive regulation of bone mineralization; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of epithelial cell migration; positive regulation of gene expression; positive regulation of ossification; positive regulation of osteoblast differentiation; positive regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of protein phosphorylation; positive regulation of SMAD protein signal transduction; positive regulation of transcription by RNA polymerase II; protein phosphorylation; pulmonary valve development; regulation of cell population proliferation; regulation of lung blood pressure; retina vasculature development in camera-type eye; semi-lunar valve development; transmembrane receptor protein serine/threonine kinase signaling pathway; tricuspid valve morphogenesis; venous blood vessel development; ventricular septum morphogenesis
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Reference #:
O35607
(UniProtKB)
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Alt. Names/Synonyms: 2610024H22Rik; AL117858; AW546137; BB189135; BMP; BMP type II receptor; BMP type-2 receptor; BMP-; BMP-2; BMPR-2; BMPR-II; Bmpr2; BMPRII; Bone morphogenetic protein receptor type II; Bone morphogenetic protein receptor type-2; bone morphogenetic protein receptor, type II (serine/threonine kinase); bone morphogenic protein receptor, type II (serine/threonine kinase); BRK-3; Gm20272
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Gene Symbols: Bmpr2
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Molecular weight:
115,020 Da
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Basal Isoelectric point:
5.83
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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