ACVR2B a tyrosine-kinase like receptor kinase of the STKR family. The holoreceptor receptor is a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Each is composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic kinase domain. Type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptor kinases are apparently constitutively active. The IIB receptor displays a 3- to 4-fold higher affinity for activin A than the II receptor. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; STKR family; TKL group; Type2 subfamily
Chromosomal Location of Human Ortholog: 9|9 F3
Cellular Component:  activin receptor complex; cytoplasm; integral component of membrane; integral component of plasma membrane; membrane; plasma membrane; protein-containing complex; receptor complex
Molecular Function:  activin binding; ATP binding; growth factor binding; inhibin binding; kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; SMAD binding; transferase activity; transforming growth factor beta receptor activity, type II; transforming growth factor beta-activated receptor activity; transmembrane receptor protein serine/threonine kinase activity; type I transforming growth factor beta receptor binding
Biological Process:  activation of protein kinase activity; activin receptor signaling pathway; anterior/posterior pattern specification; artery development; blood vessel remodeling; BMP signaling pathway; determination of left/right symmetry; embryonic foregut morphogenesis; gastrulation with mouth forming second; heart development; insulin secretion; kidney development; lung development; lymphangiogenesis; lymphatic endothelial cell differentiation; mesoderm development; negative regulation of cold-induced thermogenesis; negative regulation of transcription by RNA polymerase II; odontogenesis of dentin-containing tooth; organ growth; pancreas development; pattern specification process; phosphorylation; positive regulation of activin receptor signaling pathway; positive regulation of bone mineralization; positive regulation of osteoblast differentiation; post-embryonic development; protein phosphorylation; regulation of signal transduction; regulation of transcription, DNA-templated; response to glucose; retina vasculature development in camera-type eye; roof of mouth development; signal transduction; skeletal system development; skeletal system morphogenesis; transforming growth factor beta receptor signaling pathway; transmembrane receptor protein serine/threonine kinase signaling pathway; venous blood vessel development
Reference #:  P27040 (UniProtKB)
Alt. Names/Synonyms: activin receptor IIB; Activin receptor type IIB; Activin receptor type-2B; ACTR-IIB; ActRIIB; Acvr2b; AVR2B; MGC118477
Gene Symbols: Acvr2b
Molecular weight: 60,542 Da
Basal Isoelectric point: 5.64  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein