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ACVR2A
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.30; Kinase, protein; Membrane protein, integral; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; STKR family; STKR2 subfamily; TKL group |
| Chromosomal Location of mouse Ortholog: 2 C1.1|2 28.38 cM |
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Cellular Component:
activin receptor complex; cell surface; cytoplasm; inhibin-betaglycan-ActRII complex; membrane; plasma membrane; receptor complex
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Molecular Function:
activin binding; activin receptor activity; ATP binding; BMP receptor activity; coreceptor activity; growth factor binding; inhibin binding; kinase activity; metal ion binding; nucleotide binding; PDZ domain binding; protein binding; protein kinase activity; protein self-association; protein serine/threonine kinase activity; transferase activity; transmembrane receptor protein serine/threonine kinase activity
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Biological Process:
activin receptor signaling pathway; anterior/posterior pattern specification; BMP signaling pathway; cellular response to BMP stimulus; cellular response to growth factor stimulus; determination of left/right symmetry; embryonic skeletal system development; gastrulation with mouth forming second; male gonad development; mesoderm development; odontogenesis of dentin-containing tooth; penile erection; phosphorylation; positive regulation of activin receptor signaling pathway; positive regulation of bone mineralization; positive regulation of erythrocyte differentiation; positive regulation of follicle-stimulating hormone secretion; positive regulation of osteoblast differentiation; positive regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of protein phosphorylation; positive regulation of transcription by RNA polymerase II; protein phosphorylation; regulation of nitric oxide biosynthetic process; regulation of signal transduction; Sertoli cell proliferation; sperm ejaculation; spermatogenesis; transmembrane receptor protein serine/threonine kinase signaling pathway
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Reference #:
P27038
(UniProtKB)
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Alt. Names/Synonyms: activin receptor IIA; Activin receptor type IIA; Activin receptor type-2A; ACTR-IIA; ActrIIa; Acvr2; Acvr2a; AVR2A; OTTMUSP00000013280; tAc; TactrII
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Gene Symbols: Acvr2a
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Molecular weight:
57,890 Da
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Basal Isoelectric point:
5.61
Predict pI for various phosphorylation states
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