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BMPR1B
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.30; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; STKR family; TKL group; Type1 subfamily |
| Chromosomal Location of Human Ortholog: 3|3 H1 |
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Cellular Component:
integral component of membrane; integral component of plasma membrane; membrane; plasma membrane; receptor complex
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Molecular Function:
ATP binding; growth factor binding; kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; SMAD binding; transferase activity; transforming growth factor beta receptor activity, type I; transforming growth factor beta-activated receptor activity; transmembrane receptor protein serine/threonine kinase activity
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Biological Process:
BMP signaling pathway; camera-type eye development; cartilage condensation; cartilage development; cell differentiation; cellular response to BMP stimulus; cellular response to growth factor stimulus; chondrocyte differentiation; dorsal/ventral pattern formation; estrogen biosynthetic process; eye development; inflammatory response; limb morphogenesis; ovarian cumulus expansion; ovulation cycle; pattern specification process; phosphorylation; positive regulation of bone mineralization; positive regulation of cell differentiation; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of osteoblast differentiation; positive regulation of transcription by RNA polymerase II; protein phosphorylation; retina development in camera-type eye; retinal ganglion cell axon guidance; skeletal system development; transforming growth factor beta receptor signaling pathway; transmembrane receptor protein serine/threonine kinase signaling pathway
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Reference #:
P36898
(UniProtKB)
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Alt. Names/Synonyms: Activin receptor-like kinase 6; Acvrlk6; AI385617; ALK-6; Alk6; AV355320; BMP type-1B receptor; BMPR-1B; BMPR-IB; Bmpr1b; BMR1B; Bone morphogenetic protein receptor type-1B; bone morphogenetic protein receptor, type 1B; CFK-43a; OTTMUSP00000030749; OTTMUSP00000030751; OTTMUSP00000030767; OTTMUSP00000030768; Serine/threonine-protein kinase receptor R6; SKR6
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Gene Symbols: Bmpr1b
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Molecular weight:
56,944 Da
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Basal Isoelectric point:
7.48
Predict pI for various phosphorylation states
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